DOSSIER · 13F-HR · Q2 2026

Crestline Management, LP

$53M in tracked AUM across 3 positions as of Q2 2026.

CM
CIK 0001536054 · last filed Jun 30, 2026
Total AUM
$53M
as of Q2 2026
Holdings
3
positions
Whale Score
70
70
strong
Activity
no data
changes this Q
AI Analysis · Q2 2026

Portfolio Overview

Crestline Management, LP’s filing for the period ending September 30, 2025, reveals an extremely concentrated and high-conviction investment strategy. The total portfolio value decreased significantly by 20.8%, declining from $62.56 million in the previous quarter to $49.52 million. This reduction in assets under management (AUM) is driven by a combination of asset reallocation and market performance. The firm currently holds just one security, resulting in a complete lac...

Key Holdings

The portfolio is composed entirely of Denali Therapeutics Inc. (DNLI), a position valued at $49.52 million, representing 100% of the total assets. The firm holds 3.41 million shares of the biotechnology company. While this is the sole remaining position, the firm did reduce its exposure to DNLI during the quarter by 11.7%, a divestment of approximately $4.49 million. Despite this reduction, the decision to retain Denali as the sole holding signals strong confidence in the company's fundamental value or upcoming clinical catalysts. The position is large enough to suggest that Crestline is a significant shareholder, likely holding influence or at least a close watch on the company's operational progress.

Analysis generated by 13F Insight from SEC Form 13F filing data · Q2 2026. Methodology

Quarter at a glance — Q2 2026

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q2 2026.

#HoldingValueSharesWeight
01
DNLI
DENALI THERAPEUTICS INC
$49M1.9M91.9%
02
SANA
SANA BIOTECHNOLOGY INC
$3M756K4.9%
03
EGHT
8X8 INC NEW
$2M991K3.2%

Filing history

2026Q2Jun 30
$53M 15.6%
3 positionsView →
2026Q1Mar 31
$46M 13.2%
3 positionsView →
2025Q4Dec 31
$53M 7.7%
3 positionsView →
2025Q3Sep 30
$50M 20.8%
1 positionsView →
2025Q2Jun 30
$63M 10.6%
3 positionsLocked
2025Q1Mar 31
$57M 98.1%
1 positionsLocked
2024Q4Dec 31
$3.0B 56.3%
705 positionsLocked
2024Q3Sep 30
$1.9B 49.8%
514 positionsLocked
2024Q2Jun 30
$1.3B 13.5%
159 positionsLocked
2024Q1Mar 31
$1.1B 3.6%
157 positionsLocked
2023Q4Dec 31
$1.2B 36.7%
157 positionsLocked
2023Q3Sep 30
$858M 10.4%
143 positionsLocked
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