DOSSIER · 13F-HR · Q4 2025

Knoll Capital Management, LLC

$218M in tracked AUM across 34 positions as of Q4 2025.

KC
CIK 0001325083 · last filed Dec 31, 2025
Total AUM
$218M
as of Q4 2025
Holdings
34
positions
Whale Score
58
58
tracked
Activity
no data
changes this Q
AI Analysis · Q4 2025

1. Portfolio Overview

Knoll Capital Management’s 13F filing for the period ending September 30, 2025, reveals a concentrated, high-conviction portfolio totaling approximately $131.4 million across 22 holdings. The firm manages a relatively compact portfolio compared to larger institutional asset managers, which allows for meaningful positions in smaller or mid-cap companies.

During the quarter, the portfolio experienced a decrease in value of -6.6% (dropping from $140.65 millio...

2. Key Holdings

The portfolio is characterized by a "bar-bell" structure, with a massive overweight in a few specific biotechnology names and a smaller allocation to precious metals.

Quarter at a glance — Q4 2025

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q4 2025.

#HoldingValueSharesWeight
01
ALDX
Aldeyra Therapeutics Inc
$28M5.5M13.0%
02
G11196105
Biohaven Pharmactl Hldg Co L
$26M2.3M12.1%
03
NUVB
Nuvation Bio Inc
$13M1.5M6.2%
04
05337M104
Avadel Pharmaceuticals Plc
$13M600K5.9%
05
GLD
SPDR Gold Trust
$13M32K5.8%
06
RGLD
Royal Gold Inc.
$12M53K5.4%
07
KGC
Kinross Gold Corp
$12M410K5.3%
08
M40527109
Entera Bio Ltd
$11M5.9M5.2%
09
G59665102
MeiraGTX Holdings
$10M1.3M4.6%
10
SA
SEABRIDGE GOLD INC
$9M317K4.3%

Filing history

2025Q4Dec 31
$218M 65.9%
34 positionsView →
2025Q3Sep 30
$131M 6.6%
22 positionsView →
2025Q2Jun 30
$141M 8.5%
38 positionsLocked
2025Q1Mar 31
$154M 1.0%
36 positionsLocked
2024Q4Dec 31
$155M 28.0%
35 positionsLocked
2024Q3Sep 30
$216M 45.4%
36 positionsLocked
2024Q2Jun 30
$148M 7.7%
35 positionsLocked
2024Q1Mar 31
$161M 33.1%
34 positionsLocked
2023Q4Dec 31
$121M 25.4%
32 positionsLocked
2023Q3Sep 30
$96M 16.8%
37 positionsLocked
2023Q2Jun 30
$82M 27.1%
27 positionsLocked
2023Q1Mar 31
$65M 46.4%
26 positionsLocked
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