DOSSIER · 13F-HR · Q3 2025

New Leaf Venture Partners, L.L.C.

$41M in tracked AUM across 5 positions as of Q3 2025.

NL
CIK 0001631614 · last filed Sep 30, 2025
Total AUM
$41M
as of Q3 2025
Holdings
5
positions
Whale Score
53
53
tracked
Activity
no data
changes this Q
AI Analysis · Q3 2025

Portfolio Overview

New Leaf Venture Partners, L.L.C. presents a highly specialized, concentrated portfolio typical of a specialized healthcare or biotechnology-focused investment vehicle. As of the reporting period ending September 30, 2025, the firm manages approximately $41.34 million in assets across a mere five holdings. This extreme concentration—where the top two positions alone account for over 73% of the total portfolio value—indicates a high-conviction strategy rather than a divers...

The firm underwent a significant portfolio contraction during the quarter, with total assets under management (AUM) decreasing by 21.9%, dropping from $52.95 million to $41.34 million. This reduction was driven entirely by the liquidation of positions rather than market depreciation of existing assets, as the remaining five holdings showed no share count changes. The portfolio is currently divided between Healthcare (55.6%) and an "Unknown" sector (44.4%), which likely represents biotechnology or early-stage life sciences companies that may not yet have a standard GICS classification.

Key Holdings

Quarter at a glance — Q3 2025

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q3 2025.

#HoldingValueSharesWeight
01
EWTX
EWTX
$17M1.0M40.4%
02
ARVN
ARVN
$14M1.6M32.7%
03
CRNX
CRNX
$6M141K14.2%
04
COGT
COGT
$4M251K8.7%
05
75120L100
RLYB
$2M3.3M4.0%

Filing history

2025Q3Sep 30
$41M 21.9%
5 positionsView →
2025Q2Jun 30
$53M 21.4%
8 positionsLocked
2025Q1Mar 31
$44M 41.7%
7 positionsLocked
2024Q4Dec 31
$75M 23.1%
9 positionsLocked
2024Q3Sep 30
$97M 18.3%
10 positionsLocked
2024Q2Jun 30
$82M 28.0%
10 positionsLocked
2024Q1Mar 31
$114M 8.0%
11 positionsLocked
2023Q4Dec 31
$124M 59.4%
12 positionsLocked
2023Q3Sep 30
$78M 33.1%
12 positionsLocked
2023Q2Jun 30
$116M 3.8%
14 positionsLocked
2023Q1Mar 31
$121M 12.4%
17 positionsLocked
2022Q4Dec 31
$138M 18.0%
17 positionsLocked
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