AI Holders Summary · Q4 2025

35 institutions reported CALC in Q4 2025. DEERFIELD MANAGEMENT COMPANY, L.P. leads at 49.1% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(5 on this page)

#HolderValueShares% port.Quarter

DEERFIELD MANAGEMENT COMPANY, L.P.

CIK 0001009258

$9M1.3M0.11%Q4 2025 02

Woodline Partners LP

CIK 0001784547

$3M2.5M0.01%Q2 2026 03

HEIGHTS CAPITAL MANAGEMENT, INC

CIK 0001081698

$2M1.6M0.37%Q2 2026 04

Squadron Capital Management LLC

CIK 0002050709

$1M1.2M0.40%Q2 2026 05

STEMPOINT CAPITAL LP

CIK 0001952142

$1M1.2M0.21%Q2 2026 06

Stonepine Capital Management, LLC

CIK 0001440771

$545K622K0.31%Q2 2026 07

MERITAGE PORTFOLIO MANAGEMENT

CIK 0000881432

$405K62K0.03%Q4 2025 08

L1 Global Manager Pty Ltd

CIK 0001878742

$256K249K0.18%Q2 2026 09

Sheets Smith Investment Management

CIK 0001785199

$157K51K0.10%Q3 2025 10

MORGAN STANLEY

CIK 0000895421

$148K143K0.00%Q2 2026 11

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$114K110K0.00%Q2 2026 12

RENAISSANCE TECHNOLOGIES LLC

CIK 0001037389

$100K97K0.00%Q2 2026 13

JANE STREET GROUP, LLC

CIK 0001595888· Market maker

$96K179K0.00%Q1 2026 14

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$92K89K0.00%Q2 2026 15

180 WEALTH ADVISORS, LLC

CIK 0001730817

$86K83K0.01%Q2 2026 16

XTX Topco Ltd

CIK 0001828301

$81K78K0.00%Q2 2026 17

VANGUARD FIDUCIARY TRUST CO

CIK 0000933478· Index

$47K46K0.00%Q2 2026 18

SUSQUEHANNA INTERNATIONAL GROUP, LLP

CIK 0001446194· Market maker

$45K44K0.00%Q2 2026 19

Cambridge Investment Research Advisors, Inc.

CIK 0001419186

$32K60K0.00%Q1 2026 20

Rockefeller Capital Management L.P.

CIK 0001739439

$21K20K0.00%Q2 2026

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