AI Holders Summary · Q4 2025

175 institutions reported HRTX in Q4 2025. Rubric Capital Management LP leads at 29.4% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(2 on this page)

#HolderValueShares% port.Quarter

Rubric Capital Management LP

CIK 0001687509

$39M30.0M0.47%Q4 2025 02

Clearline Capital LP

CIK 0001600136

$16M12.2M0.78%Q4 2025 03

BlackRock, Inc.

CIK 0002012383

$8M10.1M0.00%Q1 2026 04

ORBIMED ADVISORS LLC

CIK 0001055951

$8M9.8M0.16%Q1 2026 05

Velan Capital Investment Management LP

CIK 0001848809

$7M8.8M4.39%Q1 2026 06

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$6M7.8M0.00%Q1 2026 07

MILLENNIUM MANAGEMENT LLC

CIK 0001273087

$6M7.6M0.00%Q1 2026 08

Tejara Capital Ltd

CIK 0001879713

$5M6.3M1.67%Q1 2026 09

TANG CAPITAL MANAGEMENT LLC

CIK 0001232621

$5M6.3M0.25%Q1 2026 10

PALISADE CAPITAL MANAGEMENT, LP

CIK 0001009006

$5M6.1M0.16%Q1 2026 11

D. E. Shaw & Co., Inc.

CIK 0001009207

$4M3.0M0.00%Q4 2025 12

Focus Partners Wealth

CIK 0001542153

$4M148K0.00%Q4 2025 13

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$3M4.0M0.00%Q1 2026 14

STATE STREET CORP

CIK 0000093751

$3M3.8M0.00%Q1 2026 15

JW Asset Management, LLC

CIK 0001549738

$3M3.8M1.23%Q1 2026 16

CITADEL ADVISORS LLC

CIK 0001423053

$3M2.1M0.00%Q4 2025 17

Pale Fire Capital SE

CIK 0001922318

$2M2.7M0.19%Q1 2026 18

NEW YORK STATE COMMON RETIREMENT FUND

CIK 0000810265

$2M2.6M0.00%Q1 2026 19

Caption Management, LLC

CIK 0001706766

$2M2.4M0.01%Q1 2026 20

Stonepine Capital Management, LLC

CIK 0001440771

$2M2.4M0.77%Q1 2026

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