13F Insight
DOSSIER · 13F Holders · Q1 2026Most-boughtAI cap-ex
KPTI

KARYOPHARM THERAPEUTICS INC

86 institutions still hold KARYOPHARM THERAPEUTICS INC as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 48576U205·86 13F holders·last filed Mar 31, 2026
Market cap
—
▼ 8.0%
vs prior quarter
13F value held
$110M
70.0% inst. owned
of float
Holders
86
+27 QoQ
filers reporting
Activity
+21 / −56
+887 added · −892 reduced
this quarter
Concentration
13.03%
Ikarian Capital, LLC #1
top holder share
AI Holders Summary · Q1 2026

86 institutions reported KPTI in Q1 2026. Ikarian Capital, LLC leads at 13.0% of the visible book. +27 net new institutions vs prior quarter — accumulation reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
Ikarian Capital, LLC
CIK 0001778253
$14M2.6M1.16%Q1 202602
Commodore Capital LP
CIK 0001831942
$11M1.9M0.63%Q1 202603
RA CAPITAL MANAGEMENT, L.P.
CIK 0001346824
$11M1.9M0.11%Q1 202604
ADAGE CAPITAL PARTNERS GP, L.L.C.
CIK 0001165408
$10M1.8M0.02%Q1 202605
SUSQUEHANNA INTERNATIONAL GROUP, LLP
CIK 0001446194· Market maker
$7M1.3M0.00%Q1 202606
Opaleye Management Inc.
CIK 0001595855
$7M930K0.90%Q4 202507
Caption Management, LLC
CIK 0001706766
$7M1.2M0.04%Q1 202608
Avidity Partners Management LP
CIK 0001791827
$6M927K0.69%Q1 202609
GOLDMAN SACHS GROUP INC
CIK 0000886982
$5M948K0.00%Q1 202610
Catalio Capital Management, LP
CIK 0001958125
$5M898K1.04%Q1 202611
BOOTHBAY FUND MANAGEMENT, LLC
CIK 0001549230
$4M750K0.05%Q1 202612
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$4M740K0.00%Q1 202613
JANE STREET GROUP, LLC
CIK 0001595888· Market maker
$3M594K0.00%Q1 202614
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
$3M512K0.00%Q1 202615
Affinity Asset Advisors, LLC
CIK 0001773195
$3M500K0.14%Q1 202616
Soleus Capital Management, L.P.
CIK 0001802630
$2M440K0.10%Q1 202617
ADAR1 Capital Management, LLC
CIK 0001940272
$2M342K0.11%Q1 202618
Boxer Capital Management, LLC
CIK 0002018299
$2M303K0.22%Q1 202619
DAVIDSON KEMPNER CAPITAL MANAGEMENT LP
CIK 0001595082
$2M300K0.02%Q1 202620
Eversept Partners, LP
CIK 0001697013
$2M300K0.09%Q1 2026
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