13F Insight
DOSSIER · 13F Holders · Q4 2025Healthcare · Pharmaceutical PreparationsCyclicalNet sold
OPK

OPKO HEALTH INC

246 institutions still hold OPKO HEALTH INC as of Q4 2025. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 68375N103·Pharmaceutical Preparations·246 13F holders·last filed Dec 31, 2025
Market cap
—
▲ 1.7%
vs prior quarter
13F value held
$206M
54.0% inst. owned
of float
Holders
246
-109 QoQ
filers reporting
Activity
+90 / −32
+952 added · −700 reduced
this quarter
Concentration
29.29%
Rubric Capital Management LP #1
top holder share
AI Holders Summary · Q4 2025

246 institutions reported OPK in Q4 2025. Rubric Capital Management LP leads at 29.3% of the visible book. -109 net institutions QoQ — distribution reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
Rubric Capital Management LP
CIK 0001687509
$60M47.8M0.72%Q4 202502
BlackRock, Inc.
CIK 0002012383
$41M36.2M0.00%Q1 202603
Vanguard Portfolio Management
CIK 0002100121· Index
$17M14.8M0.00%Q1 202604
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$17M14.5M0.00%Q1 202605
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$13M11.3M0.00%Q1 202606
STATE STREET CORP
CIK 0000093751
$11M9.5M0.00%Q1 202607
GOLDMAN SACHS GROUP INC
CIK 0000886982
$9M7.7M0.00%Q1 202608
UBS Group AG
CIK 0001610520
$7M6.1M0.00%Q1 202609
Whitefort Capital Management, LP
CIK 0001884931
$5M4.3M1.43%Q1 202610
NORTHERN TRUST CORP
CIK 0000073124· Index
$4M3.6M0.00%Q1 202611
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
CIK 0000884546· Index
$4M3.6M0.00%Q1 202612
CITADEL ADVISORS LLC
CIK 0001423053
$4M3.0M0.00%Q4 202513
VANGUARD FIDUCIARY TRUST CO
CIK 0000933478· Index
$3M2.7M0.00%Q1 202614
AWM Investment Company, Inc.
CIK 0001535264
$2M2.1M0.27%Q1 202615
DIMENSIONAL FUND ADVISORS LP
CIK 0000354204· Quasi-passive
$2M1.6M0.00%Q1 202616
WASHINGTON GROWTH STRATEGIES LLC
CIK 0002044575
$2M1.4M1.01%Q1 202617
Y.D. More Investments Ltd
CIK 0001870364
$1M1.3M0.06%Q1 202618
Bank of New York Mellon Corp
CIK 0001390777
$1M1.3M0.00%Q1 202619
MORGAN STANLEY
CIK 0000895421
$1M1.2M0.00%Q1 202620
JANE STREET GROUP, LLC
CIK 0001595888· Market maker
$1M1.2M0.00%Q1 2026
Page 1 of 13
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