DOSSIER · 13F-HR · Q1 2026

Blue Water Life Science Advisors, LP

$125M in tracked AUM across 10 positions as of Q1 2026.

BW
CIK 0001789778 · last filed Mar 31, 2026
Total AUM
$125M
as of Q1 2026
Holdings
10
positions
Whale Score
69
69
tracked
Activity
no data
changes this Q
AI Analysis · Q1 2026
Comprehensive Analysis of Blue Water Life Science Advisors, LP (SEC 13F)
Portfolio Overview

Blue Water Life Science Advisors, LP manages a highly concentrated, specialized portfolio with a total value of $86.83 million as of the reporting period ending September 30, 2025. The firm employs a high-conviction investment strategy, holding only six positions, which indicates a preference for selectivity over broad diversification. The portfolio experienced a significant contraction of 31.3% in ...

Key Holdings

The portfolio is dominated by Adaptive Biotechnologies (ADPT), which constitutes the largest single holding at $32.09 million, representing 36.96% of the total assets. This suggests a strong conviction in the company’s immunosequencing platform. The second-largest position, Guardant Health (GH), accounts for 29.19% of the portfolio ($25.34 million). Together, these two positions comprise over 66% of the fund's invested capital, indicating a "barbell" strategy where the firm's performance is heavily correlated with the success of its top two liquid biopsy and genomic profiling names. The remaining holdings—Personalis, CareDx, Tempus AI, and Quanterix—are smaller positions ranging from 6% to 13% of the portfolio, providing exposure to adjacent areas of precision medicine and diagnostics.

Sector Allocation

The sector allocation demonstrates an extreme concentration in the Healthcare sector, which commands $70.05 million or approximately 80.7% of the portfolio. This aligns with the firm's name ("Life Science Advisors") and suggests a thematic investment approach focused on biotechnology, diagnostics, and life sciences tools. The Technology sector accounts for $5.84 million (6.73%), entirely represented by the new position in Tempus AI. A small portion of the portfolio (12.59%) is classified as "Unknown," corresponding to Personalis, Inc. (likely due to ticker classification nuances), though this company also operates within the healthcare and diagnostics space. Effectively, the portfolio is a pure-play on the healthcare/life sciences ecosystem with negligible exposure to other sectors.

Quarter at a glance — Q1 2026

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q1 2026.

#HoldingValueSharesWeight
01
TXG
10X GENOMICS INC
$23M1.1M18.6%
02
GH
GUARDANT HEALTH INC
$22M242K17.9%
03
CDNA
CAREDX INC
$16M935K13.0%
04
ADPT
ADAPTIVE BIOTECHNOLOGIES COR
$14M1.0M11.2%
05
TWST
TWIST BIOSCIENCE CORP
$13M276K10.5%
06
PSNL
PERSONALIS INC
$11M1.7M8.6%
07
NTRA
NATERA INC
$9M45K7.2%
08
QTRX
QUANTERIX CORP
$8M2.1M6.0%
09
TEM
TEMPUS AI INC
$7M156K5.7%
10
BLLN
BILLIONTOONE INC
$2M20K1.3%

Filing history

2026Q1Mar 31
$125M 21.7%
10 positionsView →
2025Q4Dec 31
$159M 83.5%
9 positionsView →
2025Q3Sep 30
$87M 31.3%
6 positionsView →
2025Q2Jun 30
$126M 76.9%
8 positionsLocked
2025Q1Mar 31
$71M 36.7%
6 positionsLocked
2024Q4Dec 31
$113M 0.7%
9 positionsLocked
2024Q3Sep 30
$114M 10.6%
8 positionsLocked
2024Q2Jun 30
$103M 3.3%
8 positionsLocked
2024Q1Mar 31
$106M 6.9%
8 positionsLocked
2023Q4Dec 31
$114M 7.8%
9 positionsLocked
2023Q3Sep 30
$106M 28.5%
7 positionsLocked
2023Q2Jun 30
$148M 2.0%
7 positionsLocked
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