DOSSIER · 13F-HR · Q4 2025
Opaleye Management Inc.
Opaleye's family office based in Chicago, IL — $758M in tracked AUM across 54 positions as of Q4 2025.
O
Opaleye·Chicago, IL·Family Office
CIK 0001595855 · last filed Dec 31, 2025
AI Analysis · Q4 2025 · Q4 2025
Comprehensive Analysis of Opaleye Management Inc. SEC 13F Filing
Portfolio Overview
Opaleye Management Inc. manages a concentrated portfolio totaling approximately $425.45 million as of the report date September 30, 2025. The firm employs a high-conviction investment strategy, holding a relatively small number of positions (32) compared to the broader institutional landscape. The portfolio experienced significant volatility during the quarter, with total assets under management (AUM) decr...
Quarter at a glance — Q4 2025
Position-change comparison pending.
No quarter-over-quarter changes available.
Top 10 holdings
By portfolio weight as of Q4 2025.
Filing history
Filing history loading…