13F Insight
DOSSIER · 13F-HR · Q4 2025

Opaleye Management Inc.

$758M in tracked AUM across 54 positions as of Q4 2025.

OM
CIK 0001595855 · last filed Dec 31, 2025
Total AUM
$758M
as of Q4 2025
Holdings
54
—
positions
Whale Score
60
60
tracked
Activity
—
no data
changes this Q
AI Analysis · Q4 2025
Comprehensive Analysis of Opaleye Management Inc. SEC 13F Filing
Portfolio Overview

Opaleye Management Inc. manages a concentrated portfolio totaling approximately $425.45 million as of the report date September 30, 2025. The firm employs a high-conviction investment strategy, holding a relatively small number of positions (32) compared to the broader institutional landscape. The portfolio experienced significant volatility during the quarter, with total assets under management (AUM) decr...

This decline in value is attributable to a combination of realized losses from exited positions, market depreciation in existing holdings, and a substantial rotation in the portfolio's composition. The firm is highly active, evidenced by the fact that nearly half of the portfolio positions were either newly acquired or completely sold during the quarter (10 new positions and 19 exits).

Key Holdings

Quarter at a glance — Q4 2025

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q4 2025.

#HoldingValueSharesWeight
01
HROW
HARROW HEALTH INC
$191M3.9M25.2%02
LQDA
LIQUIDIA CORPORATION
$85M2.4M11.2%03
ETON
ETON PHARMACEUTICALS INC
$48M2.9M6.4%04
RYTM
RHYTHM PHARMACEUTICALS INC
$35M330K4.7%05
APGE
APOGEE THERAPEUTICS INC
$29M388K3.9%06
SNWV
SANUWAVE HEALTH INC
$29M981K3.9%07
STOK
STOKE THERAPEUTICS INC
$22M695K2.9%08
OCUL
OCULAR THERAPEUTIX INC
$19M1.6M2.6%09
M8694L137
SOL GEL TECHNOLOGIES
$19M454K2.5%10
CGON
CG ONCOLOGY INC
$17M410K2.2%

Filing history

2025Q4Dec 31
$758M▲ 78.1%
54 positionsView →2025Q3Sep 30
$425M▼ 14.7%
32 positionsView →2025Q2Jun 30
$499M▲ 76.5%
41 positionsLocked2025Q1Mar 31
$283M▼ 50.5%
33 positionsLocked2024Q4Dec 31
$571M▼ 4.7%
39 positionsLocked2024Q3Sep 30
$600M▲ 37.0%
44 positionsLocked2024Q2Jun 30
$438M▼ 4.6%
51 positionsLocked2024Q1Mar 31
$459M▲ 22.0%
52 positionsLocked2023Q4Dec 31
$376M▲ 22.3%
47 positionsLocked2023Q3Sep 30
$307M▼ 26.5%
41 positionsLocked2023Q2Jun 30
$418M▲ 25.2%
47 positionsLocked2023Q1Mar 31
$334M▲ 16.1%
41 positionsLocked
Showing 12 of 42