13F Insight
DOSSIER · 13F-HR · Q2 2026

Opaleye Management Inc.

$1.1B in tracked AUM across 58 positions as of Q2 2026.

OM
CIK 0001595855 · last filed Jun 30, 2026
Total AUM
$1.1B
as of Q2 2026
Holdings
58
—
positions
Whale Score
73
73
strong
Activity
—
no data
changes this Q
AI Analysis · Q2 2026
Comprehensive Analysis of Opaleye Management Inc. SEC 13F Filing
Portfolio Overview

Opaleye Management Inc. manages a concentrated portfolio totaling approximately $425.45 million as of the report date September 30, 2025. The firm employs a high-conviction investment strategy, holding a relatively small number of positions (32) compared to the broader institutional landscape. The portfolio experienced significant volatility during the quarter, with total assets under management (AUM) decr...

This decline in value is attributable to a combination of realized losses from exited positions, market depreciation in existing holdings, and a substantial rotation in the portfolio's composition. The firm is highly active, evidenced by the fact that nearly half of the portfolio positions were either newly acquired or completely sold during the quarter (10 new positions and 19 exits).

Key Holdings
Analysis generated by 13F Insight from SEC Form 13F filing data · Q2 2026. Methodology

Quarter at a glance — Q2 2026

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q2 2026.

#HoldingValueSharesWeight
01
LQDA
LIQUIDIA CORPORATION
$195M2.4M17.7%02
ETON
ETON PHARMACEUTICALS INC
$104M2.9M9.4%03
HROW
HARROW INC
$102M2.4M9.2%04
IRON
DISC MEDICINE INC
$63M855K5.7%05
M96088105
UROGEN PHARMA LTD
$53M1.4M4.8%06
APGE
APOGEE THERAPEUTICS INC
$52M390K4.7%07
G59665102
MEIRAGTX HLDGS PLC
$48M3.5M4.3%08
M8694L137
SOL-GEL TECHNOLOGIES LTD
$37M500K3.4%09
RZLT
REZOLUTE INC
$33M6.3M3.0%10
TGTX
TG THERAPEUTICS INC
$29M535K2.7%

Filing history

2026Q2Jun 30
$1.1B▲ 45.7%
58 positionsView →2025Q4Dec 31
$758M▲ 78.1%
54 positionsView →2025Q3Sep 30
$425M▼ 14.7%
32 positionsView →2025Q2Jun 30
$499M▲ 76.5%
41 positionsLocked2025Q1Mar 31
$283M▼ 50.5%
33 positionsLocked2024Q4Dec 31
$571M▼ 4.7%
39 positionsLocked2024Q3Sep 30
$600M▲ 37.0%
44 positionsLocked2024Q2Jun 30
$438M▼ 4.6%
51 positionsLocked2024Q1Mar 31
$459M▲ 22.0%
52 positionsLocked2023Q4Dec 31
$376M▲ 22.3%
47 positionsLocked2023Q3Sep 30
$307M▼ 26.5%
41 positionsLocked2023Q2Jun 30
$418M▲ 25.2%
47 positionsLocked
Showing 12 of 43