AI Holders Summary · Q4 2025

234 institutions reported HROW in Q4 2025. Opaleye Management Inc. leads at 27.0% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(7 on this page)

#HolderValueShares% port.Quarter

Opaleye Management Inc.

CIK 0001595855

$191M3.9M25.25%Q4 2025 02

BlackRock, Inc.

CIK 0002012383

$90M2.6M0.00%Q1 2026 03

Private Capital Management, LLC

CIK 0001588456

$57M1.6M5.63%Q1 2026 04

SUSQUEHANNA INTERNATIONAL GROUP, LLP

CIK 0001446194· Market maker

$52M1.5M0.01%Q1 2026 05

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$49M1.4M0.00%Q1 2026 06

Luxor Capital Group, LP

CIK 0001316580

$39M1.1M2.75%Q1 2026 07

CITADEL ADVISORS LLC

CIK 0001423053

$33M679K0.01%Q4 2025 08

STATE STREET CORP

CIK 0000093751

$30M855K0.00%Q1 2026 09

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$30M852K0.00%Q1 2026 10

DIMENSIONAL FUND ADVISORS LP

CIK 0000354204· Quasi-passive

$20M580K0.00%Q1 2026 11

Ikarian Capital, LLC

CIK 0001778253

$19M543K1.55%Q1 2026 12

Penn Capital Management Company, LLC

CIK 0001158202

$14M408K1.12%Q1 2026 13

RICE HALL JAMES & ASSOCIATES, LLC

CIK 0001230765

$13M368K0.72%Q1 2026 14

GOLDMAN SACHS GROUP INC

CIK 0000886982

$12M342K0.00%Q1 2026 15

NORTHERN TRUST CORP

CIK 0000073124· Index

$10M297K0.00%Q1 2026 16

Vanguard Portfolio Management

CIK 0002100121· Index

$10M289K0.00%Q1 2026 17

MARSHALL WACE, LLP

CIK 0001318757

$10M200K0.01%Q4 2025 18

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

CIK 0000884546· Index

$10M271K0.00%Q1 2026 19

NEW YORK STATE COMMON RETIREMENT FUND

CIK 0000810265

$9M269K0.01%Q1 2026 20

Blackhawk Capital Partners, LLC

CIK 0001582561

$9M203K2.82%Q2 2026

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