13F Insight
DOSSIER · 13F Holders · Q1 2026Defensive growthQuality

LEXICON PHARMACEUTICALS INC

143 institutions still hold LEXICON PHARMACEUTICALS INC as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 528872302·143 13F holders·last filed Mar 31, 2026
Market cap
—
▼ 3.9%
vs prior quarter
13F value held
$485M
68.0% inst. owned
of float
Holders
143
-92 QoQ
filers reporting
Activity
+19 / −101
+874 added · −678 reduced
this quarter
Concentration
49.80%
Artal Group S.A. #1
top holder share
AI Holders Summary · Q1 2026

143 institutions reported LEXICON PHARMACEUTICALS INC in Q1 2026. Artal Group S.A. leads at 49.8% of the visible book. -92 net institutions QoQ — distribution reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
Artal Group S.A.
CIK 0001053906
$241M154.7M23.89%Q1 202602
FMR LLC
CIK 0000315066
$70M45.1M0.00%Q1 202603
Siren, L.L.C.
CIK 0002005245
$69M44.3M1.92%Q1 202604
Sessa Capital IM, L.P.
CIK 0001595849
$28M17.9M0.51%Q1 202605
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$15M9.5M0.00%Q1 202606
Point72 Asset Management, L.P.
CIK 0001603466
$12M7.8M0.02%Q1 202607
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
$8M4.9M0.00%Q1 202608
BlackRock, Inc.
CIK 0002012383
$5M3.3M0.00%Q1 202609
JANE STREET GROUP, LLC
CIK 0001595888· Market maker
$5M3.2M0.00%Q1 202610
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$5M3.2M0.00%Q1 202611
SUSQUEHANNA INTERNATIONAL GROUP, LLP
CIK 0001446194· Market maker
$4M2.8M0.00%Q1 202612
UBS Group AG
CIK 0001610520
$4M2.5M0.00%Q1 202613
CIBC Bancorp USA Inc.
CIK 0001711924
$3M1.8M0.00%Q1 202614
CITADEL ADVISORS LLC
CIK 0001423053
$3M2.3M0.00%Q4 202515
RENAISSANCE TECHNOLOGIES LLC
CIK 0001037389
$2M1.6M0.00%Q1 202616
CIBC Private Wealth Group LLC
CIK 0001298088
$2M1.9M0.00%Q4 202517
VANGUARD FIDUCIARY TRUST CO
CIK 0000933478· Index
$2M1.3M0.00%Q1 202618
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
CIK 0000884546· Index
$2M1.3M0.00%Q1 202619
TWO SIGMA INVESTMENTS, LP
CIK 0001179392
$2M1.2M0.00%Q1 202620
GOLDMAN SACHS GROUP INC
CIK 0000886982
$2M1.1M0.00%Q1 2026
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