13F Insight
DOSSIER · 13F Holders · Q4 2025Mega-capCrowded
BCYC

BICYCLE THERAPEUTICS PLC

101 institutions still hold BICYCLE THERAPEUTICS PLC as of Q4 2025. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 088786108·101 13F holders·last filed Dec 31, 2025
Market cap
—
▲ 9.1%
vs prior quarter
13F value held
$171M
51.0% inst. owned
of float
Holders
101
+132 QoQ
filers reporting
Activity
+100 / −75
+947 added · −952 reduced
this quarter
Concentration
45.11%
BAKER BROS. ADVISORS LP #1
top holder share
AI Holders Summary · Q4 2025

101 institutions reported BCYC in Q4 2025. BAKER BROS. ADVISORS LP leads at 45.1% of the visible book. +132 net new institutions vs prior quarter — accumulation reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
BAKER BROS. ADVISORS LP
CIK 0001263508
$77M10.9M0.45%Q4 202502
FCPM III SERVICES B.V.
CIK 0002013410
$16M3.5M2.23%Q1 202603
ARMISTICE CAPITAL, LLC
CIK 0001601086
$16M3.4M0.28%Q1 202604
Long Focus Capital Management, LLC
CIK 0001602716
$15M3.3M0.40%Q1 202605
Siren, L.L.C.
CIK 0002005245
$7M1.6M0.20%Q1 202606
GSK plc
CIK 0001131399
$7M1.5M1.18%Q1 202607
PRINCIPAL FINANCIAL GROUP INC
CIK 0001126328
$5M1.2M0.00%Q1 202608
RENAISSANCE TECHNOLOGIES LLC
CIK 0001037389
$5M979K0.01%Q1 202609
MORGAN STANLEY
CIK 0000895421
$3M618K0.00%Q1 202610
SCHRODER INVESTMENT MANAGEMENT GROUP
CIK 0001086619
$3M616K0.00%Q1 202611
CITADEL ADVISORS LLC
CIK 0001423053
$2M313K0.00%Q4 202512
DIADEMA PARTNERS LP
CIK 0002026172
$2M476K0.38%Q1 202613
Birchview Capital, LP
CIK 0001618205
$2M464K1.22%Q1 202614
SILVERCREST ASSET MANAGEMENT GROUP LLC
CIK 0001232395
$2M429K0.01%Q1 202615
Qube Research & Technologies Ltd
CIK 0001729829
$1M309K0.00%Q1 202616
JANE STREET GROUP, LLC
CIK 0001595888· Market maker
$1M303K0.00%Q1 202617
SUSQUEHANNA INTERNATIONAL GROUP, LLP
CIK 0001446194· Market maker
$1M297K0.00%Q1 202618
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
$1M284K0.00%Q1 202619
BlackRock, Inc.
CIK 0002012383
$1M279K0.00%Q1 202620
MOORE CAPITAL MANAGEMENT, LP
CIK 0001448574
$1M275K0.03%Q1 2026
Page 1 of 6
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