DOSSIER · 13F-HR · Q4 2025

BAKER BROS. ADVISORS LP

BAKER BROS.'s asset manager based in Boston, MA — $17.1B in tracked AUM across 86 positions as of Q4 2025.

BB

BAKER BROS.·Boston, MA·Asset Manager

CIK 0001263508 · last filed Dec 31, 2025

Total AUM

$17.1B

▲ 9.8%

vs prior

Holdings

86

—

positions

Whale Score

75

75

strong

Activity

—

no data

changes this Q

Top sector

Tech

35% weight

concentration

AI Analysis · Q4 2025 · Q4 2025

Comprehensive Analysis of Baker Bros. Advisors LP SEC 13F Filing (Q3 2025)

Portfolio Overview

Baker Bros. Advisors LP manages a concentrated portfolio valued at approximately $10.18 billion as of September 30, 2025. The fund experienced a slight contraction of -1.3% in total value compared to the previous quarter ($10.31B), amidst a period of significant portfolio turnover. The fund currently holds 67 positions, indicating a focused investment strategy rather than broad diversi...

Quarter at a glance — Q4 2025

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q4 2025.

#HoldingValueSharesWeight

01

Incyte Corporation

$3.0B30.7M17.8%

02

BeOne Medicines Ltd.

$2.7B8.8M15.7%

03

Madrigal Pharmaceuticals, Inc.

$1.2B2.1M7.3%

04

Insmed Incorporated

$1.1B6.6M6.7%

05

ACADIA Pharmaceuticals Inc.

$1.1B42.9M6.7%

06

Celcuity Inc.

$790M7.9M4.6%

07

Revolution Medicines, Inc.

$753M9.5M4.4%

08

Kymera Therapeutics, Inc.

$674M8.7M3.9%

09

Summit Therapeutics Inc.

$636M36.4M3.7%

10

Rhythm Pharmaceuticals, Inc.

$600M5.6M3.5%

Filing history

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