DOSSIER · 13F Holders · Q4 2025Healthcare · Pharmaceutical Preparations
ACAD

ACADIA PHARMACEUTICALS INC

372 institutions still hold ACADIA PHARMACEUTICALS INC as of Q4 2025. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 004225108·Pharmaceutical Preparations·372 13F holders·last filed Dec 31, 2025
Market cap
13F value held
$3.3B
visible holders
Holders
372
filers reporting
Concentration
34.71%
BAKER BROS. ADVISORS LP #1
top holder share
AI Holders Summary · Q4 2025

Burney Co. sold 50,921 shares of Acadia Pharmaceuticals this quarter, cutting its stake by 85% — from 59,970 shares down to just 9,049. It's the sharpest real retreat in the filing, worth roughly $1.29 million in genuine selling, and unlike the quarter's other big seller it isn't an index-linked fund: Burney is a discretionary manager that appears to have made an active decision to walk away from most of its position. Assenagon Asset Management, a fund 13F Insight classifies as quasi-passive, cut even harder in dollar terms — $1.44 million, a 73% reduction — though that move more likely reflects an index mandate change than a view on the stock. Against those two exits, buying was broad: Hennion & Walsh Asset Management, still the largest holder at 24.5% of the $10.7 million in institutional value 13F Insight can see, added modestly (up 2.5%), and Gradient Investments, Diversified Trust Co and Empirical Wealth Management all built more meaningfully (up 13.3%, 3%, and nearly 20% respectively). First Citizens Bank & Trust opened the quarter's largest new position at $619,394, one of five new entrants.

Assenagon Asset Management sold even more in dollar terms — $1.44 million, a 73% reduction from 78,127 down to 21,052 shares. But Assenagon is a fund 13F Insight's own data classifies as quasi-passive, which points to an index mandate change behind the sale rather than a considered view on Acadia specifically. Between the two, more than $2.7 million left the stock's institutional base in real selling this quarter — a meaningful sum against a total tracked value of just $10.7 million.

Against those two exits, the rest of the register was buying. Hennion & Walsh Asset Management, still the largest holder at 24.5% of the $10.7 million in institutional value 13F Insight can see, added a modest 2.5% (100,729 to 103,290 shares). Gradient Investments built more aggressively, up 13.3% (28,900 to 32,738 shares) worth roughly $97,101 in real buying. Empirical Wealth Management grew its stake nearly 20% (12,923 to 15,489 shares), and Diversified Trust Co added a smaller 3% on top of an already sizable position.

Analysis generated by 13F Insight from SEC Form 13F filing data · Q4 2025. Methodology

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
BAKER BROS. ADVISORS LP
CIK 0001263508
$1.1B42.9M6.71%Q4 2025
02
BlackRock, Inc.
CIK 0002012383
$570M22.5M0.01%Q2 2026
03
STATE STREET CORP
CIK 0000093751
$230M9.1M0.01%Q2 2026
04
Vanguard Portfolio Management
CIK 0002100121· Index
$224M8.8M0.01%Q2 2026
05
RTW INVESTMENTS, LP
CIK 0001493215
$181M7.1M1.54%Q2 2026
06
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$146M5.8M0.00%Q2 2026
07
DIMENSIONAL FUND ADVISORS LP
CIK 0000354204· Quasi-passive
$93M3.7M0.02%Q2 2026
08
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$85M3.4M0.00%Q2 2026
09
Palo Alto Investors LP
CIK 0001306923
$72M2.9M10.01%Q2 2026
10
GOLDMAN SACHS GROUP INC
CIK 0000886982
$65M2.6M0.01%Q2 2026
11
Qube Research & Technologies Ltd
CIK 0001729829
$62M2.4M0.06%Q2 2026
12
Point72 Asset Management, L.P.
CIK 0001603466
$58M2.6M0.07%Q1 2026
13
CITADEL ADVISORS LLC
CIK 0001423053
$58M2.3M0.01%Q2 2026
14
BRAIDWELL LP
CIK 0001920938
$55M2.5M1.83%Q1 2026
15
Pictet Asset Management Holding SA
CIK 0001993888
$50M2.0M0.05%Q2 2026
16
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP
CIK 0001164508
$50M2.0M0.02%Q2 2026
17
MARSHALL WACE, LLP
CIK 0001318757
$45M1.8M0.04%Q2 2026
18
NORGES BANK
CIK 0001374170· Sovereign
$41M1.6M0.00%Q2 2026
19
Frazier Life Sciences Management, L.P.
CIK 0001892134
$36M1.4M0.79%Q2 2026
20
NORTHERN TRUST CORP
CIK 0000073124· Index
$35M1.4M0.00%Q2 2026
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Insiders at ACADIA PHARMACEUTICALS INC
Schneyer Mark C.Thompson Elizabeth H.Z.Kihara JamesDaly James MPoole JonathanGarofalo Elizabeth A.Brege LauraHarrigan Edmund