DOSSIER · 13F Holders · Q4 2025Healthcare · Pharmaceutical Preparations
ACAD

ACADIA PHARMACEUTICALS INC

363 institutions still hold ACADIA PHARMACEUTICALS INC as of Q4 2025. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 004225108·Pharmaceutical Preparations·363 13F holders·last filed Dec 31, 2025
Market cap
13F value held
$3.0B
visible holders
Holders
363
filers reporting
Concentration
38.42%
BAKER BROS. ADVISORS LP #1
top holder share
AI Holders Summary · Q4 2025

Burney Co. sold 50,921 shares of Acadia Pharmaceuticals this quarter, cutting its stake by 85% — from 59,970 shares down to just 9,049. It's the sharpest real retreat in the filing, worth roughly $1.29 million in genuine selling, and unlike the quarter's other big seller it isn't an index-linked fund: Burney is a discretionary manager that appears to have made an active decision to walk away from most of its position. Assenagon Asset Management, a fund 13F Insight classifies as quasi-passive, cut even harder in dollar terms — $1.44 million, a 73% reduction — though that move more likely reflects an index mandate change than a view on the stock. Against those two exits, buying was broad: Hennion & Walsh Asset Management, still the largest holder at 24.5% of the $10.7 million in institutional value 13F Insight can see, added modestly (up 2.5%), and Gradient Investments, Diversified Trust Co and Empirical Wealth Management all built more meaningfully (up 13.3%, 3%, and nearly 20% respectively). First Citizens Bank & Trust opened the quarter's largest new position at $619,394, one of five new entrants.

Assenagon Asset Management sold even more in dollar terms — $1.44 million, a 73% reduction from 78,127 down to 21,052 shares. But Assenagon is a fund 13F Insight's own data classifies as quasi-passive, which points to an index mandate change behind the sale rather than a considered view on Acadia specifically. Between the two, more than $2.7 million left the stock's institutional base in real selling this quarter — a meaningful sum against a total tracked value of just $10.7 million.

Against those two exits, the rest of the register was buying. Hennion & Walsh Asset Management, still the largest holder at 24.5% of the $10.7 million in institutional value 13F Insight can see, added a modest 2.5% (100,729 to 103,290 shares). Gradient Investments built more aggressively, up 13.3% (28,900 to 32,738 shares) worth roughly $97,101 in real buying. Empirical Wealth Management grew its stake nearly 20% (12,923 to 15,489 shares), and Diversified Trust Co added a smaller 3% on top of an already sizable position.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
BAKER BROS. ADVISORS LP
CIK 0001263508
$1.1B42.9M6.71%Q4 2025
02
BlackRock, Inc.
CIK 0002012383
$480M21.6M0.01%Q1 2026
03
Vanguard Portfolio Management
CIK 0002100121· Index
$193M8.7M0.01%Q1 2026
04
STATE STREET CORP
CIK 0000093751
$185M8.3M0.01%Q1 2026
05
RTW INVESTMENTS, LP
CIK 0001493215
$159M7.1M1.58%Q1 2026
06
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$126M5.7M0.00%Q1 2026
07
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$77M3.5M0.00%Q1 2026
08
FIRST TRUST ADVISORS LP
CIK 0001125816· Index
$74M3.3M0.05%Q1 2026
09
DIMENSIONAL FUND ADVISORS LP
CIK 0000354204· Quasi-passive
$70M3.2M0.01%Q1 2026
10
Palo Alto Investors LP
CIK 0001306923
$64M2.9M9.78%Q1 2026
11
Point72 Asset Management, L.P.
CIK 0001603466
$58M2.6M0.07%Q1 2026
12
BRAIDWELL LP
CIK 0001920938
$55M2.5M1.83%Q1 2026
13
Pictet Asset Management Holding SA
CIK 0001993888
$45M2.0M0.05%Q1 2026
14
RENAISSANCE TECHNOLOGIES LLC
CIK 0001037389
$38M1.7M0.06%Q1 2026
15
Trails Edge Capital Partners, LP
CIK 0002077247
$38M1.4M9.37%Q4 2025
16
CITADEL ADVISORS LLC
CIK 0001423053
$38M1.4M0.01%Q4 2025
17
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP
CIK 0001164508
$35M1.6M0.02%Q1 2026
18
GOLDMAN SACHS GROUP INC
CIK 0000886982
$35M1.6M0.00%Q1 2026
19
BANK OF AMERICA CORP /DE/
CIK 0000070858
$35M1.6M0.00%Q1 2026
20
Frazier Life Sciences Management, L.P.
CIK 0001892134
$32M1.4M0.82%Q1 2026
Page 1 of 19
343 more holders available. Log in →
Insiders at ACADIA PHARMACEUTICALS INC
Kihara JamesDaly James MPoole JonathanGarofalo Elizabeth A.Brege LauraHarrigan EdmundNdu AdoraSchneyer Mark C.