Palo Alto Investors LP

Comprehensive Analysis of Palo Alto Investors LP (SEC 13F) – Q3 2025

1. Portfolio Overview

Palo Alto Investors LP manages a concentrated, high-conviction portfolio characterized by a significant reduction in size and a pivot towards specific healthcare sub-sectors. As of the report date September 30, 2025, the total portfolio value stands at approximately $341.95 million, representing a sharp decrease of 27.2% from the previous quarter's $470.00 million.

The portfolio is highly concentra...