DOSSIER · 13F-HR · Q1 2026

Palo Alto Investors LP

Palo Alto Investors's asset manager based in Chicago, IL $654M in tracked AUM across 51 positions as of Q1 2026.

PA
Palo Alto Investors·Chicago, IL·Asset Manager
CIK 0001306923 · last filed Mar 31, 2026
Total AUM
$654M
9.9%
vs prior
Holdings
51
positions
Whale Score
66
66
tracked
Activity
no data
changes this Q
Top sector
Financials
4% weight
concentration
AI Analysis · Q1 2026 · Q1 2026
Comprehensive Analysis of Palo Alto Investors LP (SEC 13F) – Q3 2025
1. Portfolio Overview

Palo Alto Investors LP manages a concentrated, high-conviction portfolio characterized by a significant reduction in size and a pivot towards specific healthcare sub-sectors. As of the report date September 30, 2025, the total portfolio value stands at approximately $341.95 million, representing a sharp decrease of 27.2% from the previous quarter's $470.00 million.

The portfolio is highly concentra...

Quarter at a glance — Q1 2026

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q1 2026.

#HoldingValueSharesWeight
01
INSM
INSMED INC
$68M415K10.4%
02
ACAD
ACADIA PHARMACEUTICALS INC
$64M2.9M9.8%
03
PTCT
PTC THERAPEUTICS INC
$63M922K9.6%
04
BMRN
BIOMARIN PHARMACEUTICAL INC
$39M685K5.9%
05
UTHR
UNITED THERAPEUTICS CORP
$37M63K5.7%
06
ANAB
ANAPTYSBIO INC
$35M638K5.4%
07
MIRM
MIRUM PHARMACEUTICALS INC
$30M325K4.6%
08
DYN
DYNE THERAPEUTICS INC
$30M1.7M4.6%
09
BIIB
BIOGEN INC
$26M141K3.9%
10
IRON
DISC MEDICINE INC
$26M402K3.9%

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