13F Insight
DOSSIER · 13F Holders · Q4 2025Healthcare · Pharmaceutical PreparationsMega-capCrowded
MDGL

MADRIGAL PHARMACEUTICALS INC

400 institutions still hold MADRIGAL PHARMACEUTICALS INC as of Q4 2025. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 558868105·Pharmaceutical Preparations·400 13F holders·last filed Dec 31, 2025
Market cap
—
▼ 1.5%
vs prior quarter
13F value held
$9.1B
53.0% inst. owned
of float
Holders
400
+127 QoQ
filers reporting
Activity
+30 / −59
+901 added · −882 reduced
this quarter
Concentration
13.75%
BAKER BROS. ADVISORS LP #1
top holder share
AI Holders Summary · Q4 2025

400 institutions reported MDGL in Q4 2025. BAKER BROS. ADVISORS LP leads at 13.8% of the visible book. +127 net new institutions vs prior quarter — accumulation reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
BAKER BROS. ADVISORS LP
CIK 0001263508
$1.2B2.1M7.30%Q4 202502
JANUS HENDERSON GROUP PLC
CIK 0001274173
$1.1B2.0M0.50%Q1 202603
RTW INVESTMENTS, LP
CIK 0001493215
$1.0B2.0M10.38%Q1 202604
Avoro Capital Advisors LLC
CIK 0001633313
$952M1.8M9.36%Q1 202605
BlackRock, Inc.
CIK 0002012383
$817M1.6M0.01%Q1 202606
PAULSON & CO. INC.
CIK 0001035674
$729M1.4M23.42%Q1 202607
Vanguard Portfolio Management
CIK 0002100121
$440M841K0.02%Q1 202608
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$433M827K0.01%Q1 202609
WELLINGTON MANAGEMENT GROUP LLP
CIK 0000902219
$364M695K0.07%Q1 202610
STATE STREET CORP
CIK 0000093751
$319M610K0.01%Q1 202611
FMR LLC
CIK 0000315066
$268M512K0.01%Q1 202612
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$239M456K0.01%Q1 202613
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC
CIK 0001644956
$178M341K0.59%Q1 202614
Invesco Ltd.
CIK 0000914208
$172M330K0.03%Q1 202615
Polar Capital Holdings Plc
CIK 0001837309
$151M289K0.54%Q1 202616
GOLDMAN SACHS GROUP INC
CIK 0000886982
$145M277K0.02%Q1 202617
ARMISTICE CAPITAL, LLC
CIK 0001601086
$139M265K2.46%Q1 202618
Hood River Capital Management LLC
CIK 0001578177
$131M250K1.31%Q1 202619
SUSQUEHANNA INTERNATIONAL GROUP, LLP
CIK 0001446194· Market maker
$126M241K0.01%Q1 202620
JANE STREET GROUP, LLC
CIK 0001595888· Market maker
$125M239K0.02%Q1 2026
Page 1 of 20
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