DOSSIER · 13F Holders · Q4 2025Healthcare · Pharmaceutical Preparations
MDGL

MADRIGAL PHARMACEUTICALS INC

402 institutions still hold MADRIGAL PHARMACEUTICALS INC as of Q4 2025. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 558868105·Pharmaceutical Preparations·402 13F holders·last filed Dec 31, 2025
Market cap
13F value held
$9.1B
visible holders
Holders
402
filers reporting
Concentration
13.68%
BAKER BROS. ADVISORS LP #1
top holder share
AI Holders Summary · Q4 2025

Only three of Madrigal Pharmaceuticals' 25 institutional holders reported any reduction this quarter, and the largest — Eastern Bank, cutting 24.4% of its shares (86 to 65) — moved just $10,116, a rounding error next to the scale of buying elsewhere. That buying is dominated by one fund: Assenagon Asset Management, flagged quasi_passive, grew its position more than sevenfold, from 16,033 to 124,214 shares, a genuine $58.1 million increase that now makes it 84.6% of the stock's $78.8 million in tracked institutional value. Because of Assenagon's classification, that surge likely reflects index-weighting mechanics — possibly tied to the stock's market-cap growth — rather than a discretionary conviction call, even though the dollar figure dwarfs everything else in the holder table.

One fund now owns 84.6% of the tracked book

Assenagon Asset Management's position grew more than sevenfold this quarter: 16,033 shares to 124,214, a genuine $58.1 million increase in flow terms that pushed its share of the stock's $78.8 million in tracked institutional value to 84.6%. Because Assenagon is flagged quasi_passive in this dataset, a jump of this scale more plausibly reflects index-weighting mechanics — Madrigal's market capitalization likely grew enough to increase its weight in whatever index Assenagon tracks — than a discretionary bet by an active manager. Still, the dollar figure is real and now defines the entire stock's institutional ownership picture.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
BAKER BROS. ADVISORS LP
CIK 0001263508
$1.2B2.1M7.30%Q4 2025
02
JANUS HENDERSON GROUP PLC
CIK 0001274173
$1.1B2.0M0.50%Q1 2026
03
RTW INVESTMENTS, LP
CIK 0001493215
$1.0B2.0M10.38%Q1 2026
04
Avoro Capital Advisors LLC
CIK 0001633313
$952M1.8M9.36%Q1 2026
05
BlackRock, Inc.
CIK 0002012383
$817M1.6M0.01%Q1 2026
06
PAULSON & CO. INC.
CIK 0001035674
$729M1.4M23.42%Q1 2026
07
Vanguard Portfolio Management
CIK 0002100121· Index
$440M841K0.02%Q1 2026
08
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$433M827K0.01%Q1 2026
09
WELLINGTON MANAGEMENT GROUP LLP
CIK 0000902219
$364M695K0.07%Q1 2026
10
STATE STREET CORP
CIK 0000093751
$319M610K0.01%Q1 2026
11
FMR LLC
CIK 0000315066
$268M512K0.01%Q1 2026
12
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$239M456K0.01%Q1 2026
13
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC
CIK 0001644956
$178M341K0.59%Q1 2026
14
Invesco Ltd.
CIK 0000914208
$172M330K0.02%Q1 2026
15
PRICE T ROWE ASSOCIATES INC /MD/
CIK 0000080255
$172M328K0.02%Q1 2026
16
Polar Capital Holdings Plc
CIK 0001837309
$151M289K0.54%Q1 2026
17
GOLDMAN SACHS GROUP INC
CIK 0000886982
$145M277K0.02%Q1 2026
18
ARMISTICE CAPITAL, LLC
CIK 0001601086
$139M265K2.46%Q1 2026
19
Hood River Capital Management LLC
CIK 0001578177
$131M250K1.31%Q1 2026
20
LORD, ABBETT & CO. LLC
CIK 0000728100
$127M243K0.41%Q1 2026
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Insiders at MADRIGAL PHARMACEUTICALS INC
Sibold William JohnFouse Jacqualyn ALevy Richard STaub RebeccaSoergel DavidDier MardiHuntsman Carole