DOSSIER · 13F Holders · Q4 2025Healthcare · Pharmaceutical Preparations
MDGL

MADRIGAL PHARMACEUTICALS INC

427 institutions still hold MADRIGAL PHARMACEUTICALS INC as of Q4 2025. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 558868105·Pharmaceutical Preparations·427 13F holders·last filed Dec 31, 2025
Market cap
13F value held
$10.2B
visible holders
Holders
427
filers reporting
Concentration
12.19%
BAKER BROS. ADVISORS LP #1
top holder share
AI Holders Summary · Q4 2025

Only three of Madrigal Pharmaceuticals' 25 institutional holders reported any reduction this quarter, and the largest — Eastern Bank, cutting 24.4% of its shares (86 to 65) — moved just $10,116, a rounding error next to the scale of buying elsewhere. That buying is dominated by one fund: Assenagon Asset Management, flagged quasi_passive, grew its position more than sevenfold, from 16,033 to 124,214 shares, a genuine $58.1 million increase that now makes it 84.6% of the stock's $78.8 million in tracked institutional value. Because of Assenagon's classification, that surge likely reflects index-weighting mechanics — possibly tied to the stock's market-cap growth — rather than a discretionary conviction call, even though the dollar figure dwarfs everything else in the holder table.

One fund now owns 84.6% of the tracked book

Assenagon Asset Management's position grew more than sevenfold this quarter: 16,033 shares to 124,214, a genuine $58.1 million increase in flow terms that pushed its share of the stock's $78.8 million in tracked institutional value to 84.6%. Because Assenagon is flagged quasi_passive in this dataset, a jump of this scale more plausibly reflects index-weighting mechanics — Madrigal's market capitalization likely grew enough to increase its weight in whatever index Assenagon tracks — than a discretionary bet by an active manager. Still, the dollar figure is real and now defines the entire stock's institutional ownership picture.

Analysis generated by 13F Insight from SEC Form 13F filing data · Q4 2025. Methodology

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
BAKER BROS. ADVISORS LP
CIK 0001263508
$1.2B2.1M7.30%Q4 2025
02
RTW INVESTMENTS, LP
CIK 0001493215
$1.1B2.0M9.14%Q2 2026
03
JANUS HENDERSON GROUP PLC
CIK 0001274173
$1.1B2.0M0.50%Q1 2026
04
Jupiter Topco LLC
CIK 0002146052
$1.0B1.9M0.42%Q2 2026
05
Avoro Capital Advisors LLC
CIK 0001633313
$984M1.8M8.84%Q2 2026
06
PAULSON & CO. INC.
CIK 0001035674
$720M1.3M27.94%Q2 2026
07
BlackRock, Inc.
CIK 0002012383
$645M1.2M0.01%Q2 2026
08
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$449M836K0.01%Q2 2026
09
WELLINGTON MANAGEMENT GROUP LLP
CIK 0000902219
$443M826K0.08%Q2 2026
10
Vanguard Portfolio Management
CIK 0002100121· Index
$420M782K0.02%Q2 2026
11
CITADEL ADVISORS LLC
CIK 0001423053
$369M688K0.04%Q2 2026
12
STATE STREET CORP
CIK 0000093751
$283M527K0.01%Q2 2026
13
SUSQUEHANNA INTERNATIONAL GROUP, LLP
CIK 0001446194· Market maker
$240M447K0.02%Q2 2026
14
UBS Group AG
CIK 0001610520
$216M402K0.03%Q2 2026
15
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$201M375K0.01%Q2 2026
16
FMR LLC
CIK 0000315066
$191M356K0.01%Q2 2026
17
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC
CIK 0001644956
$174M324K0.52%Q2 2026
18
PRICE T ROWE ASSOCIATES INC /MD/
CIK 0000080255
$172M328K0.02%Q1 2026
19
Invesco Ltd.
CIK 0000914208
$162M301K0.01%Q2 2026
20
ARMISTICE CAPITAL, LLC
CIK 0001601086
$155M288K1.89%Q2 2026
Page 1 of 22
407 more holders available. Log in →
Insiders at MADRIGAL PHARMACEUTICALS INC
Kelley Shannon TSibold William JohnFouse Jacqualyn ALevy Richard STaub RebeccaSoergel DavidDier MardiHuntsman Carole