13F Insight
DOSSIER · 13F Holders · Q4 2025Healthcare · Pharmaceutical PreparationsBellwetherCompounder
RYTM

RHYTHM PHARMACEUTICALS INC

294 institutions still hold RHYTHM PHARMACEUTICALS INC as of Q4 2025. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 76243J105·Pharmaceutical Preparations·294 13F holders·last filed Dec 31, 2025
Market cap
—
▲ 1.6%
vs prior quarter
13F value held
$4.4B
46.0% inst. owned
of float
Holders
294
+84 QoQ
filers reporting
Activity
+66 / −88
+897 added · −843 reduced
this quarter
Concentration
13.61%
BAKER BROS. ADVISORS LP #1
top holder share
AI Holders Summary · Q4 2025

294 institutions reported RYTM in Q4 2025. BAKER BROS. ADVISORS LP leads at 13.6% of the visible book. +84 net new institutions vs prior quarter — accumulation reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
BAKER BROS. ADVISORS LP
CIK 0001263508
$600M5.6M3.51%Q4 202502
RA CAPITAL MANAGEMENT, L.P.
CIK 0001346824
$580M6.7M6.14%Q1 202603
BlackRock, Inc.
CIK 0002012383
$542M6.2M0.01%Q1 202604
PRIMECAP MANAGEMENT CO/CA/
CIK 0000763212
$297M3.4M0.23%Q1 202605
Vanguard Portfolio Management
CIK 0002100121
$264M3.0M0.01%Q1 202606
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$258M3.0M0.01%Q1 202607
PERCEPTIVE ADVISORS LLC
CIK 0001224962
$206M2.4M4.03%Q1 202608
STATE STREET CORP
CIK 0000093751
$198M2.3M0.01%Q1 202609
GOLDMAN SACHS GROUP INC
CIK 0000886982
$171M2.0M0.02%Q1 202610
WESTFIELD CAPITAL MANAGEMENT CO LP
CIK 0001177719
$168M1.9M0.70%Q1 202611
FMR LLC
CIK 0000315066
$147M1.7M0.01%Q1 202612
Polar Capital Holdings Plc
CIK 0001837309
$141M1.6M0.50%Q1 202613
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$123M1.4M0.01%Q1 202614
JPMORGAN CHASE & CO
CIK 0000019617
$120M1.6M0.01%Q1 202615
FEDERATED HERMES, INC.
CIK 0001056288
$112M1.3M0.18%Q1 202616
Checkpoint Capital L.P.
CIK 0001977548
$107M1.2M38.30%Q1 202617
JENNISON ASSOCIATES LLC
CIK 0000053417
$98M919K0.06%Q4 202518
ALLIANCEBERNSTEIN L.P.
CIK 0001109448
$97M910K0.03%Q1 202619
Capital Research Global Investors
CIK 0001422848
$97M1.1M0.02%Q1 202620
JANUS HENDERSON GROUP PLC
CIK 0001274173
$80M918K0.04%Q1 2026
Page 1 of 15
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