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Filers›Hedge Fund›RA CAPITAL MANAGEMENT, L.P.
DOSSIER · 13F-HR · Q1 2026

RA CAPITAL MANAGEMENT, L.P.

RA , L.P.'s hedge fund based in Omaha, NE — $9.4B in tracked AUM across 86 positions as of Q1 2026.

R,
RA , L.P.·Omaha, NE·Hedge Fund
CIK 0001346824 · last filed Mar 31, 2026
Total AUM
$9.4B
▼ 11.5%
vs prior
Holdings
86
—
positions
Whale Score
79
79
strong
Activity
—
no data
changes this Q
Top sector
Health Care
15% weight
concentration
AI Analysis · Q1 2026 · Q1 2026
Comprehensive Analysis of RA Capital Management, L.P. SEC 13F Filing
Portfolio Overview

RA Capital Management, L.P. manages a concentrated portfolio valued at approximately $5.83 billion as of September 30, 2025. The fund employs a high-conviction strategy, evidenced by the relatively low number of holdings (44) compared to the total assets under management. The portfolio experienced a slight contraction of -1.8% in total value during the quarter, decreasing from $5.94 billion....

Quarter at a glance — Q1 2026

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q1 2026.

#HoldingValueSharesWeight
01
ASND
ASCENDIS PHARMA A/S - ADR
$2.4B10.3M24.9%
02
PCVX
VAXCYTE INC
$667M11.5M7.1%
03
RYTM
RHYTHM PHARMACEUTICALS INC
$580M6.7M6.1%
04
TYRA
TYRA BIOSCIENCES INC
$467M12.2M5.0%
05
SION
SIONNA THERAPEUTICS INC
$397M9.9M4.2%
06
EWTX
EDGEWISE THERAPEUTICS INC
$328M10.4M3.5%
07
N62509109
NEWAMSTERDAM PHARMA CO NV
$306M9.6M3.2%
08
NUVL
NUVALENT INC-A
$260M2.5M2.8%
09
DNTH
DIANTHUS THERAPEUTICS INC
$219M2.6M2.3%
10
MLYS
MINERALYS THERAPEUTICS INC
$208M7.7M2.2%

Filing history

Filing history loading…
AI Agent · grounded in RA
haiku-4-5 · 86 positions indexed
Sector mix
  • Health Care15%
  • Cons. Disc.36%
  • Communications6%
  • Industrials7%
  • Energy8%
  • Other28%
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