AI Holders Summary · Q1 2026

170 institutions reported TYRA in Q1 2026. RA CAPITAL MANAGEMENT, L.P. leads at 23.0% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(2 on this page)

#HolderValueShares% port.Quarter

RA CAPITAL MANAGEMENT, L.P.

CIK 0001346824

$467M12.2M4.95%Q1 2026 02

FMR LLC

CIK 0000315066

$297M7.7M0.02%Q1 2026 03

JANUS HENDERSON GROUP PLC

CIK 0001274173

$149M3.9M0.07%Q1 2026 04

FARALLON CAPITAL MANAGEMENT LLC

CIK 0000909661

$137M3.6M0.78%Q1 2026 05

TCG Crossover Management, LLC

CIK 0001839948

$124M3.2M3.56%Q1 2026 06

Alta Partners Management Company, L.P.

CIK 0002054419

$122M3.8M95.92%Q2 2026 07

Nextech Invest, Ltd.

CIK 0001595430

$107M4.1M10.31%Q4 2025 08

Commodore Capital LP

CIK 0001831942

$95M2.5M5.48%Q1 2026 09

BlackRock, Inc.

CIK 0002012383

$85M2.2M0.00%Q1 2026 10

Paradigm Biocapital Advisors LP

CIK 0001855655

$79M2.1M1.61%Q1 2026 11

BVF INC/IL

CIK 0001056807

$56M2.1M1.88%Q4 2025 12

Caligan Partners LP

CIK 0001727492

$49M1.3M3.25%Q1 2026 13

STATE STREET CORP

CIK 0000093751

$47M1.2M0.00%Q1 2026 14

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$43M1.1M0.00%Q1 2026 15

PRICE T ROWE ASSOCIATES INC /MD/

CIK 0000080255

$38M986K0.00%Q1 2026 16

Logos Global Management LP

CIK 0001792126

$33M850K1.63%Q1 2026 17

BARCLAYS PLC

CIK 0000312069

$32M833K0.01%Q1 2026 18

5AM Venture Management, LLC

CIK 0001799883

$27M1.0M8.51%Q4 2025 19

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$25M658K0.00%Q1 2026 20

Canaan Partners XI LLC

CIK 0001850694

$24M750K18.82%Q2 2026

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