AI Holders Summary · Q2 2026

176 institutions reported TYRA in Q2 2026. RA CAPITAL MANAGEMENT, L.P. leads at 20.6% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(2 on this page)

#HolderValueShares% port.Quarter

RA CAPITAL MANAGEMENT, L.P.

CIK 0001346824

$390M12.2M3.39%Q2 2026 02

FMR LLC

CIK 0000315066

$285M8.9M0.01%Q2 2026 03

JANUS HENDERSON GROUP PLC

CIK 0001274173

$149M3.9M0.07%Q1 2026 04

Jupiter Topco LLC

CIK 0002146052

$139M4.4M0.06%Q2 2026 05

Alta Partners Management Company, L.P.

CIK 0002054419

$122M3.8M95.92%Q2 2026 06

Nextech Invest, Ltd.

CIK 0001595430

$107M4.1M10.31%Q4 2025 07

TCG Crossover Management, LLC

CIK 0001839948

$104M3.2M2.49%Q2 2026 08

BlackRock, Inc.

CIK 0002012383

$97M3.0M0.00%Q2 2026 09

STATE STREET CORP

CIK 0000093751

$68M2.1M0.00%Q2 2026 10

Commodore Capital LP

CIK 0001831942

$60M1.9M3.57%Q2 2026 11

Paradigm Biocapital Advisors LP

CIK 0001855655

$58M1.8M1.09%Q2 2026 12

BVF INC/IL

CIK 0001056807

$56M2.1M1.88%Q4 2025 13

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$48M1.5M0.00%Q2 2026 14

PRICE T ROWE ASSOCIATES INC /MD/

CIK 0000080255

$38M986K0.00%Q1 2026 15

5AM Venture Management, LLC

CIK 0001799883

$33M1.0M11.42%Q2 2026 16

Hood River Capital Management LLC

CIK 0001578177

$32M1.0M0.24%Q2 2026 17

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$31M971K0.00%Q2 2026 18

Caligan Partners LP

CIK 0001727492

$26M807K1.21%Q2 2026 19

Canaan Partners XI LLC

CIK 0001850694

$24M750K18.82%Q2 2026 20

Siren, L.L.C.

CIK 0002005245

$23M725K0.47%Q2 2026

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