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Filers›Family Office›Paradigm Biocapital Advisors LP
DOSSIER · 13F-HR · Q1 2026

Paradigm Biocapital Advisors LP

Paradigm Biocapital's family office based in San Francisco, CA — $4.9B in tracked AUM across 35 positions as of Q1 2026.

PB
Paradigm Biocapital·San Francisco, CA·Family Office
CIK 0001855655 · last filed Mar 31, 2026
Total AUM
$4.9B
▼ 12.4%
vs prior
Holdings
35
—
positions
Whale Score
72
72
strong
Activity
—
no data
changes this Q
Top sector
Tech
35% weight
concentration
AI Analysis · Q1 2026 · Q1 2026

Portfolio Overview

Paradigm Biocapital Advisors LP manages a concentrated, high-conviction portfolio totaling approximately $2.80 billion as of September 30, 2025. The firm experienced significant growth during the quarter, with total assets under management (AUM) increasing by 19.7%, up from $2.34 billion in the previous quarter. This growth likely stems from a combination of strong market performance in underlying biotech holdings and active capital deployment.

The portfolio is highly co...

Quarter at a glance — Q1 2026

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q1 2026.

#HoldingValueSharesWeight
01
ACLX
ARCELLX INC
$663M5.8M13.5%
02
RVMD
REVOLUTION MEDICINES INC
$647M6.7M13.2%
03
NUVL
NUVALENT INC
$545M5.3M11.1%
04
PCVX
VAXCYTE INC
$279M4.8M5.7%
05
EWTX
EDGEWISE THERAPEUTICS INC
$232M7.4M4.7%
06
GMAB
GENMAB A/S
$214M8.0M4.4%
07
INSM
INSMED INC
$205M1.3M4.2%
08
TARS
TARSUS PHARMACEUTICALS INC
$180M2.6M3.7%
09
BLTE
BELITE BIO INC
$178M1.1M3.6%
10
ERAS
ERASCA INC
$168M10.4M3.4%

Filing history

Filing history loading…
AI Agent · grounded in Paradigm
haiku-4-5 · 35 positions indexed
Sector mix
  • Tech35%
  • Financials17%
  • Health Care9%
  • Cons. Disc.4%
  • Industrials8%
  • Energy24%
  • Other3%
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