AI Holders Summary · Q1 2026

206 institutions reported SYRE in Q1 2026. FMR LLC leads at 19.8% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(2 on this page)

#HolderValueShares% port.Quarter

FMR LLC

CIK 0000315066

$594M11.8M0.03%Q1 2026 02

BlackRock, Inc.

CIK 0002012383

$278M5.5M0.00%Q1 2026 03

RTW INVESTMENTS, LP

CIK 0001493215

$210M4.2M2.09%Q1 2026 04

Fairmount Funds Management LLC

CIK 0001802528

$203M4.0M14.64%Q1 2026 05

PERCEPTIVE ADVISORS LLC

CIK 0001224962

$191M3.8M3.73%Q1 2026 06

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$154M3.1M0.00%Q1 2026 07

DRIEHAUS CAPITAL MANAGEMENT LLC

CIK 0000938206

$141M2.8M1.03%Q1 2026 08

STATE STREET CORP

CIK 0000093751

$131M2.6M0.00%Q1 2026 09

VR Adviser, LLC

CIK 0001615982

$121M3.7M5.96%Q4 2025 10

Paradigm Biocapital Advisors LP

CIK 0001855655

$99M2.0M2.02%Q1 2026 11

Commodore Capital LP

CIK 0001831942

$96M1.9M5.58%Q1 2026 12

TCG Crossover Management, LLC

CIK 0001839948

$96M1.9M2.74%Q1 2026 13

TANG CAPITAL MANAGEMENT LLC

CIK 0001232621

$95M1.9M4.85%Q1 2026 14

WELLINGTON MANAGEMENT GROUP LLP

CIK 0000902219

$92M1.8M0.02%Q1 2026 15

Capital International Investors

CIK 0001562230

$88M1.7M0.02%Q1 2026 16

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$87M1.7M0.01%Q1 2026 17

JANUS HENDERSON GROUP PLC

CIK 0001274173

$84M1.7M0.04%Q1 2026 18

RA CAPITAL MANAGEMENT, L.P.

CIK 0001346824

$82M1.6M0.87%Q1 2026 19

PRICE T ROWE ASSOCIATES INC /MD/

CIK 0000080255

$81M1.6M0.01%Q1 2026 20

Remedium Capital Partners, LLC

CIK 0002104501

$73M1.5M26.13%Q1 2026

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