AI Holders Summary · Q2 2026

269 institutions reported SYRE in Q2 2026. FMR LLC leads at 21.2% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(3 on this page)

#HolderValueShares% port.Quarter

FMR LLC

CIK 0000315066

$1.2B13.0M0.05%Q2 2026 02

BlackRock, Inc.

CIK 0002012383

$578M6.5M0.01%Q2 2026 03

RTW INVESTMENTS, LP

CIK 0001493215

$377M4.3M3.22%Q2 2026 04

Paradigm Biocapital Advisors LP

CIK 0001855655

$341M3.8M6.38%Q2 2026 05

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$306M3.4M0.01%Q2 2026 06

STATE STREET CORP

CIK 0000093751

$271M3.1M0.01%Q2 2026 07

DRIEHAUS CAPITAL MANAGEMENT LLC

CIK 0000938206

$249M2.8M1.44%Q2 2026 08

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$239M2.6M0.01%Q2 2026 09

Vanguard Portfolio Management

CIK 0002100121· Index

$207M2.3M0.01%Q2 2026 10

Capital World Investors

CIK 0001422849

$206M2.3M0.02%Q2 2026 11

Jupiter Topco LLC

CIK 0002146052

$196M2.2M0.08%Q2 2026 12

PERCEPTIVE ADVISORS LLC

CIK 0001224962

$191M3.8M3.73%Q1 2026 13

TCG Crossover Management, LLC

CIK 0001839948

$169M1.9M4.06%Q2 2026 14

BANK OF AMERICA CORP /DE/

CIK 0000070858

$158M1.8M0.01%Q2 2026 15

ADAGE CAPITAL PARTNERS GP, L.L.C.

CIK 0001165408

$153M1.7M0.21%Q2 2026 16

WELLINGTON MANAGEMENT GROUP LLP

CIK 0000902219

$140M1.6M0.02%Q2 2026 17

GOLDMAN SACHS GROUP INC

CIK 0000886982

$131M1.5M0.01%Q2 2026 18

FRANKLIN RESOURCES INC

CIK 0000038777

$131M1.5M0.03%Q2 2026 19

Remedium Capital Partners, LLC

CIK 0002104501

$130M1.5M28.78%Q2 2026 20

VR Adviser, LLC

CIK 0001615982

$121M3.7M5.96%Q4 2025

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