13F Insight
DOSSIER · 13F Holders · Q1 2026High-convictionMulti-bagger
SYRE

SPYRE THERAPEUTICS INC

203 institutions still hold SPYRE THERAPEUTICS INC as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 00773J202·203 13F holders·last filed Mar 31, 2026
Market cap
—
▲ 1.8%
vs prior quarter
13F value held
$3.0B
75.0% inst. owned
of float
Holders
203
-4 QoQ
filers reporting
Activity
+8 / −44
+814 added · −731 reduced
this quarter
Concentration
19.94%
FMR LLC #1
top holder share
AI Holders Summary · Q1 2026

203 institutions reported SYRE in Q1 2026. FMR LLC leads at 19.9% of the visible book. -4 net institutions QoQ — distribution reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
FMR LLC
CIK 0000315066
$594M11.8M0.03%Q1 202602
BlackRock, Inc.
CIK 0002012383
$278M5.5M0.00%Q1 202603
RTW INVESTMENTS, LP
CIK 0001493215
$210M4.2M2.09%Q1 202604
Fairmount Funds Management LLC
CIK 0001802528
$203M4.0M14.64%Q1 202605
PERCEPTIVE ADVISORS LLC
CIK 0001224962
$191M3.8M3.73%Q1 202606
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$154M3.1M0.00%Q1 202607
DRIEHAUS CAPITAL MANAGEMENT LLC
CIK 0000938206
$141M2.8M1.03%Q1 202608
STATE STREET CORP
CIK 0000093751
$131M2.6M0.00%Q1 202609
VR Adviser, LLC
CIK 0001615982
$121M3.7M5.96%Q4 202510
Paradigm Biocapital Advisors LP
CIK 0001855655
$99M2.0M2.02%Q1 202611
Commodore Capital LP
CIK 0001831942
$96M1.9M5.58%Q1 202612
TCG Crossover Management, LLC
CIK 0001839948
$96M1.9M2.74%Q1 202613
TANG CAPITAL MANAGEMENT LLC
CIK 0001232621
$95M1.9M4.85%Q1 202614
WELLINGTON MANAGEMENT GROUP LLP
CIK 0000902219
$92M1.8M0.02%Q1 202615
Capital International Investors
CIK 0001562230
$88M1.7M0.02%Q1 202616
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$87M1.7M0.01%Q1 202617
JANUS HENDERSON GROUP PLC
CIK 0001274173
$84M1.7M0.04%Q1 202618
RA CAPITAL MANAGEMENT, L.P.
CIK 0001346824
$82M1.6M0.87%Q1 202619
Remedium Capital Partners, LLC
CIK 0002104501
$73M1.5M26.13%Q1 202620
Affinity Asset Advisors, LLC
CIK 0001773195
$65M1.3M3.33%Q1 2026
Page 1 of 11
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