DOSSIER · 13F-HR · Q1 2026

TCG Crossover Management, LLC

TCG Crossover's family office based in Omaha, NE — $3.5B in tracked AUM across 49 positions as of Q1 2026.

TC

TCG Crossover·Omaha, NE·Family Office

CIK 0001839948 · last filed Mar 31, 2026

Total AUM

$3.5B

▼ 2.7%

vs prior

Holdings

49

—

positions

Whale Score

72

72

strong

Activity

—

no data

changes this Q

Top sector

Tech

44% weight

concentration

AI Analysis · Q1 2026 · Q1 2026

Comprehensive Analysis of TCG Crossover Management, LLC 13F Filing

Portfolio Overview

TCG Crossover Management, LLC manages a concentrated, high-conviction portfolio totaling approximately $1.52 billion as of the report date September 30, 2025. This represents a significant portfolio expansion of +73.9% (an increase of roughly $645 million) compared to the $875.51 million reported in the previous quarter.

The portfolio is highly concentrated, consisting of only 30 holdings. Th...

Quarter at a glance — Q1 2026

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q1 2026.

#HoldingValueSharesWeight

01

ABIVAX SA AMERICAN DEPOSITARY SHARES

$722M6.5M20.6%

02

CG ONCOLOGY INC

$248M3.7M7.1%

03

TANGO THERAPEUTICS INC

$220M10.5M6.3%

04

COGENT BIOSCIENCES INC

$190M4.9M5.4%

05

CENTESSA PHARMACEUTICALS PLC

$170M4.3M4.9%

06

DIANTHUS THERAPEUTICS INC

$141M1.7M4.0%

07

TYRA BIOSCIENCES INC

$124M3.2M3.6%

08

IMMUNOVANT INC

$111M4.5M3.2%

09

BIOCRYST PHARMACEUTICALS INC

$105M11.0M3.0%

10

MIRUM PHARMACEUTICALS INC

$98M1.1M2.8%

Filing history

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