DOSSIER · 13F-HR · Q4 2025

5AM Venture Management, LLC

5AM Venture's family office based in London, UK $318M in tracked AUM across 21 positions as of Q4 2025.

5V
5AM Venture·London, UK·Family Office
CIK 0001799883 · last filed Dec 31, 2025
Total AUM
$318M
5.4%
vs prior
Holdings
21
positions
Whale Score
55
55
tracked
Activity
no data
changes this Q
Top sector
Tech
8% weight
concentration
AI Analysis · Q4 2025 · Q4 2025
Comprehensive Analysis of 5AM Venture Management LLC 13F Filing (Q3 2025)
Portfolio Overview

5AM Venture Management LLC reported a significant contraction in portfolio value during the quarter ending September 30, 2025. The total assets under management (AUM) decreased by 17.2%, falling from $260.12 million to $215.38 million. Despite this reduction in value, the fund maintains a highly focused investment strategy, holding exactly 20 securities. The portfolio is characterized by high conce...

Quarter at a glance — Q4 2025

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q4 2025.

#HoldingValueSharesWeight
01
TRDA
ENTRADA THERAPEUTICS INC
$42M4.1M13.1%
02
CAMP
CAMP4 THERAPEUTICS CORP
$36M5.9M11.3%
03
TYRA
TYRA BIOSCIENCES INC
$27M1.0M8.5%
04
VRDN
VIRIDIAN THERAPEUTICS INC
$23M737K7.2%
05
N69605108
PHARVARIS N V
$22M798K7.0%
06
ERAS
ERASCA INC
$20M5.4M6.3%
07
EYPT
EYEPOINT INC
$19M1.1M6.0%
08
MPLT
MAPLIGHT THERAPEUTICS INC
$17M950K5.2%
09
CNTA
CENTESSA PHARMACEUTICALS PLC
$15M581K4.6%
10
CLDX
CELLDEX THERAPEUTICS INC NEW
$14M497K4.2%

Filing history

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