AI Holders Summary · Q4 2025

133 institutions reported TRDA in Q4 2025. BAKER BROS. ADVISORS LP leads at 23.2% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(2 on this page)

#HolderValueShares% port.Quarter

BAKER BROS. ADVISORS LP

CIK 0001263508

$52M5.1M0.31%Q4 2025 02

5AM Venture Management, LLC

CIK 0001799883

$30M4.1M10.37%Q2 2026 03

MPM ASSET MANAGEMENT LLC

CIK 0001263048

$25M4.4M59.74%Q3 2025 04

BlackRock, Inc.

CIK 0002012383

$19M2.6M0.00%Q2 2026 05

Merck & Co., Inc.

CIK 0000310158

$13M1.7M2.43%Q2 2026 06

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$9M1.3M0.00%Q2 2026 07

MPM BioImpact LLC

CIK 0001687078

$9M1.3M0.56%Q2 2026 08

TCG Crossover Management, LLC

CIK 0001839948

$8M1.1M0.19%Q2 2026 09

WELLINGTON MANAGEMENT GROUP LLP

CIK 0000902219

$7M954K0.00%Q2 2026 10

PRICE T ROWE ASSOCIATES INC /MD/

CIK 0000080255

$7M526K0.00%Q1 2026 11

MILLENNIUM MANAGEMENT LLC

CIK 0001273087

$6M764K0.00%Q2 2026 12

StepStone Group LP

CIK 0001502287

$6M761K0.26%Q2 2026 13

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$5M717K0.00%Q2 2026 14

AQR CAPITAL MANAGEMENT LLC

CIK 0001167557

$5M700K0.00%Q2 2026 15

Nantahala Capital Management, LLC

CIK 0001472322

$4M601K0.07%Q2 2026 16

STATE STREET CORP

CIK 0000093751

$4M597K0.00%Q2 2026 17

JACOBS LEVY EQUITY MANAGEMENT, INC

CIK 0000884414

$4M334K0.02%Q1 2026 18

ACADIAN ASSET MANAGEMENT LLC

CIK 0000916542

$4M333K0.01%Q1 2026 19

JPMORGAN CHASE & CO

CIK 0000019617

$4M496K0.00%Q2 2026 20

CITADEL ADVISORS LLC

CIK 0001423053

$3M394K0.00%Q2 2026

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