DOSSIER · 13F-HR · Q1 2026

Commodore Capital LP

$1.7B in tracked AUM across 36 positions as of Q1 2026.

CC
CIK 0001831942 · last filed Mar 31, 2026
Total AUM
$1.7B
as of Q1 2026
Holdings
36
positions
Whale Score
72
72
strong
Activity
no data
changes this Q
AI Analysis · Q1 2026
Comprehensive Analysis of Commodore Capital LP SEC 13F Filing
Portfolio Overview

Commodore Capital LP manages a concentrated, high-conviction portfolio totaling approximately $1.39 billion as of the report date September 30, 2025. The fund employs a focused investment strategy, holding only 26 securities, which indicates a preference for selecting specific winners rather than broad market diversification. The portfolio experienced a slight contraction of 1.8% in value during t...

The fund exhibits a distinct "barbell" structure in terms of position sizing. A single position, Merus N V, commands a dominant 23.85% of the portfolio, representing a massive, high-conviction bet. The remaining 75% of the portfolio is distributed across the other 25 holdings, with most positions falling between 2% and 8%, suggesting a tiered approach where the fund manager allocates heavily to the best idea while maintaining meaningful exposure to a select list of other opportunities.

Key Holdings

Quarter at a glance — Q1 2026

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q1 2026.

#HoldingValueSharesWeight
01
RLAY
RELAY THERAPEUTICS INC
$169M17.0M9.8%
02
G01767105
ALKERMES PLC
$149M4.2M8.6%
03
ELVN
ENLIVEN THERAPEUTICS INC
$128M3.3M7.4%
04
COGT
COGENT BIOSCIENCES INC
$111M2.9M6.4%
05
SYRE
SPYRE THERAPEUTICS INC
$96M1.9M5.6%
06
TYRA
TYRA BIOSCIENCES INC
$95M2.5M5.5%
07
CLDX
CELLDEX THERAPEUTICS INC NEW
$86M2.7M4.9%
08
NUVL
NUVALENT INC
$85M834K4.9%
09
AMLX
AMYLYX PHARMACEUTICALS INC
$79M5.7M4.5%
10
KYMR
KYMERA THERAPEUTICS INC
$62M750K3.6%

Filing history

2026Q1Mar 31
$1.7B 15.1%
36 positionsView →
2025Q4Dec 31
$1.5B 8.0%
33 positionsView →
2025Q3Sep 30
$1.4B 1.8%
26 positionsView →
2025Q2Jun 30
$1.4B 44.4%
33 positionsLocked
2025Q1Mar 31
$981M 28.1%
25 positionsLocked
2024Q4Dec 31
$1.4B 14.7%
31 positionsLocked
2024Q3Sep 30
$1.6B 9.2%
36 positionsLocked
2024Q2Jun 30
$1.5B 2.0%
35 positionsLocked
2024Q1Mar 31
$1.5B 30.7%
39 positionsLocked
2023Q4Dec 31
$1.1B 33.8%
32 positionsLocked
2023Q3Sep 30
$856M 3.9%
30 positionsLocked
2023Q2Jun 30
$890M 35.5%
26 positionsLocked
Showing 12 of 22