13F Insight
DOSSIER · 13F Holders · Q1 2026Defensive growthQuality
SEPN

SEPTERNA INC

130 institutions still hold SEPTERNA INC as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 81734D104·130 13F holders·last filed Mar 31, 2026
Market cap
—
▲ 8.4%
vs prior quarter
13F value held
$1.0B
53.0% inst. owned
of float
Holders
130
+32 QoQ
filers reporting
Activity
+29 / −11
+1,008 added · −872 reduced
this quarter
Concentration
16.30%
RA CAPITAL MANAGEMENT, L.P. #1
top holder share
AI Holders Summary · Q1 2026

130 institutions reported SEPN in Q1 2026. RA CAPITAL MANAGEMENT, L.P. leads at 16.3% of the visible book. +32 net new institutions vs prior quarter — accumulation reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
RA CAPITAL MANAGEMENT, L.P.
CIK 0001346824
$168M7.0M1.78%Q1 202602
TRV GP V, LLC
CIK 0001990717
$149M6.2M37.25%Q1 202603
DRIEHAUS CAPITAL MANAGEMENT LLC
CIK 0000938206
$106M4.4M0.78%Q1 202604
TRV GP VI, LLC
CIK 0001990716
$101M4.2M74.64%Q1 202605
Samsara BioCapital, LLC
CIK 0001744967
$76M3.1M7.35%Q1 202606
GOLDMAN SACHS GROUP INC
CIK 0000886982
$70M2.9M0.01%Q1 202607
Siren, L.L.C.
CIK 0002005245
$48M2.0M1.33%Q1 202608
BVF INC/IL
CIK 0001056807
$48M1.7M1.61%Q4 202509
BlackRock, Inc.
CIK 0002012383
$44M1.8M0.00%Q1 202610
Avoro Capital Advisors LLC
CIK 0001633313
$32M1.3M0.32%Q1 202611
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$29M1.2M0.00%Q1 202612
ADAR1 Capital Management, LLC
CIK 0001940272
$26M1.1M1.54%Q1 202613
PRIMECAP MANAGEMENT CO/CA/
CIK 0000763212
$25M1.0M0.02%Q1 202614
JANUS HENDERSON GROUP PLC
CIK 0001274173
$21M891K0.01%Q1 202615
First Light Asset Management, LLC
CIK 0001600004
$18M733K1.58%Q1 202616
VR Adviser, LLC
CIK 0001615982
$17M611K0.84%Q4 202517
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$16M645K0.00%Q1 202618
STATE STREET CORP
CIK 0000093751
$15M631K0.00%Q1 202619
Casdin Capital, LLC
CIK 0001534261
$13M553K1.01%Q1 202620
Kalehua Capital Management LLC
CIK 0002106181
$9M389K3.60%Q1 2026
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