AI Holders Summary · Q2 2026

159 institutions reported SEPN in Q2 2026. RA CAPITAL MANAGEMENT, L.P. leads at 16.4% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(2 on this page)

#HolderValueShares% port.Quarter

RA CAPITAL MANAGEMENT, L.P.

CIK 0001346824

$234M7.0M2.04%Q2 2026 02

TRV GP V, LLC

CIK 0001990717

$208M6.2M41.78%Q2 2026 03

DRIEHAUS CAPITAL MANAGEMENT LLC

CIK 0000938206

$148M4.4M0.86%Q2 2026 04

TRV GP VI, LLC

CIK 0001990716

$141M4.2M60.72%Q2 2026 05

GOLDMAN SACHS GROUP INC

CIK 0000886982

$103M3.1M0.01%Q2 2026 06

Samsara BioCapital, LLC

CIK 0001744967

$76M3.1M7.35%Q1 2026 07

BlackRock, Inc.

CIK 0002012383

$65M1.9M0.00%Q2 2026 08

Siren, L.L.C.

CIK 0002005245

$64M1.9M1.29%Q2 2026 09

BVF INC/IL

CIK 0001056807

$48M1.7M1.61%Q4 2025 10

Avoro Capital Advisors LLC

CIK 0001633313

$45M1.3M0.40%Q2 2026 11

Jupiter Topco LLC

CIK 0002146052

$44M1.3M0.02%Q2 2026 12

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$41M1.2M0.00%Q2 2026 13

PRIMECAP MANAGEMENT CO/CA/

CIK 0000763212

$39M1.2M0.02%Q2 2026 14

First Light Asset Management, LLC

CIK 0001600004

$32M963K1.96%Q2 2026 15

ADAR1 Capital Management, LLC

CIK 0001940272

$32M941K1.44%Q2 2026 16

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$23M679K0.00%Q2 2026 17

Caption Management, LLC

CIK 0001706766

$23M678K0.11%Q2 2026 18

STATE STREET CORP

CIK 0000093751

$22M653K0.00%Q2 2026 19

JANUS HENDERSON GROUP PLC

CIK 0001274173

$21M891K0.01%Q1 2026 20

LOOMIS SAYLES & CO L P

CIK 0000312348

$21M625K0.03%Q2 2026

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