AI Holders Summary · Q4 2025

279 institutions reported CELC in Q4 2025. BAKER BROS. ADVISORS LP leads at 19.0% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(3 on this page)

#HolderValueShares% port.Quarter

BAKER BROS. ADVISORS LP

CIK 0001263508

$790M7.9M4.62%Q4 2025 02

Avoro Capital Advisors LLC

CIK 0001633313

$388M3.6M3.82%Q1 2026 03

PERCEPTIVE ADVISORS LLC

CIK 0001224962

$357M3.1M6.97%Q1 2026 04

RTW INVESTMENTS, LP

CIK 0001493215

$347M3.0M3.45%Q1 2026 05

BlackRock, Inc.

CIK 0002012383

$309M2.7M0.01%Q1 2026 06

NEA Management Company, LLC

CIK 0001512848

$261M2.3M14.83%Q1 2026 07

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$203M1.8M0.01%Q1 2026 08

STATE STREET CORP

CIK 0000093751

$173M1.5M0.01%Q1 2026 09

DEERFIELD MANAGEMENT COMPANY, L.P.

CIK 0001009258

$171M1.7M2.18%Q4 2025 10

MORGAN STANLEY

CIK 0000895421

$154M1.3M0.01%Q1 2026 11

Soleus Capital Management, L.P.

CIK 0001802630

$147M1.3M5.94%Q1 2026 12

PRICE T ROWE ASSOCIATES INC /MD/

CIK 0000080255

$146M1.3M0.02%Q1 2026 13

TANG CAPITAL MANAGEMENT LLC

CIK 0001232621

$120M1.1M6.09%Q1 2026 14

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$102M891K0.01%Q1 2026 15

TORONTO DOMINION BANK

CIK 0000947263

$101M883K0.14%Q1 2026 16

GOLDMAN SACHS GROUP INC

CIK 0000886982

$87M765K0.01%Q1 2026 17

BANK OF AMERICA CORP /DE/

CIK 0000070858

$82M714K0.01%Q1 2026 18

SUSQUEHANNA INTERNATIONAL GROUP, LLP

CIK 0001446194· Market maker

$79M695K0.01%Q1 2026 19

Sofinnova Investments, Inc.

CIK 0001631134

$76M666K2.89%Q1 2026 20

Caption Management, LLC

CIK 0001706766

$68M600K0.40%Q1 2026

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