13F Insight
DOSSIER · 13F Holders · Q1 2026Healthcare · Pharmaceutical PreparationsInflation hedgeYield
IONS

IONIS PHARMACEUTICALS INC

510 institutions still hold IONIS PHARMACEUTICALS INC as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 462222100·Pharmaceutical Preparations·510 13F holders·last filed Mar 31, 2026
Market cap
—
▲ 7.1%
vs prior quarter
13F value held
$9.1B
72.0% inst. owned
of float
Holders
510
-11 QoQ
filers reporting
Activity
+86 / −52
+792 added · −774 reduced
this quarter
Concentration
20.35%
FMR LLC #1
top holder share
AI Holders Summary · Q1 2026

510 institutions reported IONS in Q1 2026. FMR LLC leads at 20.4% of the visible book. -11 net institutions QoQ — distribution reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
FMR LLC
CIK 0000315066
$1.8B24.6M0.10%Q1 202602
Capital World Investors
CIK 0001422849
$1.6B21.2M0.22%Q1 202603
BlackRock, Inc.
CIK 0002012383
$784M10.4M0.01%Q1 202604
Vanguard Portfolio Management
CIK 0002100121
$586M7.8M0.03%Q1 202605
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$535M7.1M0.01%Q1 202606
WELLINGTON MANAGEMENT GROUP LLP
CIK 0000902219
$480M6.4M0.09%Q1 202607
TWO SIGMA INVESTMENTS, LP
CIK 0001179392
$440M5.9M0.35%Q1 202608
Bellevue Group AG
CIK 0001674546
$380M4.8M7.20%Q4 202509
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$305M4.0M0.02%Q1 202610
STATE STREET CORP
CIK 0000093751
$300M4.0M0.01%Q1 202611
ROYAL BANK OF CANADA
CIK 0001000275
$285M3.8M0.05%Q1 202612
TWO SIGMA ADVISERS, LP
CIK 0001478735
$241M3.1M0.47%Q4 202513
Tweedy, Browne Co LLC
CIK 0000732905
$195M2.5M15.74%Q4 202514
CITADEL ADVISORS LLC
CIK 0001423053
$183M2.3M0.03%Q4 202515
JPMORGAN CHASE & CO
CIK 0000019617
$171M2.4M0.01%Q1 202616
DEERFIELD MANAGEMENT COMPANY, L.P.
CIK 0001009258
$157M2.0M2.00%Q4 202517
Artisan Partners Limited Partnership
CIK 0001466153
$155M2.1M0.25%Q1 202618
Deep Track Capital, LP
CIK 0001856083
$146M1.9M2.39%Q1 202619
BAKER BROS. ADVISORS LP
CIK 0001263508
$142M1.8M0.83%Q4 202520
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC
CIK 0001638555
$139M1.9M3.74%Q1 2026
Page 1 of 26
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