DOSSIER · 13F Holders · Q2 2026Healthcare · Pharmaceutical Preparations
IONS

IONIS PHARMACEUTICALS INC

531 institutions still hold IONIS PHARMACEUTICALS INC as of Q2 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 462222100·Pharmaceutical Preparations·531 13F holders·last filed Jun 30, 2026
Market cap
13F value held
$10.2B
visible holders
Holders
531
filers reporting
Concentration
19.24%
FMR LLC #1
top holder share
AI Holders Summary · Q2 2026

In contrast to Q1 2026 when domestic wealth manager Davenport & Co LLC single-handedly anchored institutional volume in Ionis Pharmaceuticals Inc (IONS), Q2 2026 witnessed a surge in broad international institutional buying. Swedbank AB executed the quarter's largest buy-side move, deploying $5.03 million in net inflows to expand its holding to $7.59 million (95,666 shares). Quantitative firm Y-Intercept (Hong Kong) Ltd established a new $5.34 million stake (67,374 shares), while Davenport & Co expanded its #1 position by adding $3.63 million in net flow to reach $22.51 million (283,960 shares, 35.37% of reported 13F capital). Across 71 tracked filers, total institutional value reached $63.66 million.

A concerted inflow from European, Asian, and US institutional managers defined Ionis Pharmaceuticals Inc's (IONS) Q2 2026 holdings, pushing total tracked 13F capital to $63.66 million across 71 reporting filers.

Institutional Buyer & Seller Breakdown

Analysis generated by 13F Insight from SEC Form 13F filing data · Q2 2026. Methodology

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
FMR LLC
CIK 0000315066
$2.0B24.6M0.08%Q2 2026
02
Capital World Investors
CIK 0001422849
$1.7B21.7M0.20%Q2 2026
03
BlackRock, Inc.
CIK 0002012383
$849M10.7M0.01%Q2 2026
04
Vanguard Portfolio Management
CIK 0002100121· Index
$623M7.9M0.03%Q2 2026
05
WELLINGTON MANAGEMENT GROUP LLP
CIK 0000902219
$607M7.7M0.10%Q2 2026
06
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$572M7.2M0.01%Q2 2026
07
TWO SIGMA INVESTMENTS, LP
CIK 0001179392
$496M6.3M0.36%Q2 2026
08
ROYAL BANK OF CANADA
CIK 0001000275
$490M6.2M0.07%Q2 2026
09
T. Rowe Price Investment Management, Inc.
CIK 0001897612
$462M6.2M0.32%Q1 2026
10
STATE STREET CORP
CIK 0000093751
$344M4.3M0.01%Q2 2026
11
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$295M3.6M0.02%Q2 2026
12
TWO SIGMA ADVISERS, LP
CIK 0001478735
$241M3.1M0.47%Q4 2025
13
PRICE T ROWE ASSOCIATES INC /MD/
CIK 0000080255
$227M3.0M0.03%Q1 2026
14
JPMORGAN CHASE & CO
CIK 0000019617
$216M2.7M0.01%Q2 2026
15
Artisan Partners Limited Partnership
CIK 0001466153
$209M2.6M0.33%Q2 2026
16
Tweedy, Browne Co LLC
CIK 0000732905
$181M2.3M13.70%Q2 2026
17
Deep Track Capital, LP
CIK 0001856083
$174M2.2M2.54%Q2 2026
18
SUSQUEHANNA INTERNATIONAL GROUP, LLP
CIK 0001446194· Market maker
$169M2.1M0.01%Q2 2026
19
GOLDMAN SACHS GROUP INC
CIK 0000886982
$167M2.1M0.01%Q2 2026
20
DEERFIELD MANAGEMENT COMPANY, L.P.
CIK 0001009258
$157M2.0M2.00%Q4 2025
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Insiders at IONIS PHARMACEUTICALS INC
Bennett C FrankMonia Brett PO'Neil Patrick R.Birchler BrianHayden Michael RBerthelsen Spencer RHerman Joan EHantson Ludwig