DOSSIER · 13F Holders · Q1 2026
MLYS

MINERALYS THERAPEUTICS INC

224 institutions still hold MINERALYS THERAPEUTICS INC as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 603170101·224 13F holders·last filed Mar 31, 2026
Market cap
13F value held
$1.7B
visible holders
Holders
224
filers reporting
Concentration
12.50%
Catalys Pacific, LLC #1
top holder share
AI Holders Summary · Q1 2026

Mineralys Therapeutics Inc. (MLYS, CUSIP 603170101) entered Q1 2026 with $2.5B of institutional 13F value across 205 institutional accounts — a holder profile appropriate for a clinical-stage biopharmaceutical company whose lead program (a selective mineralocorticoid receptor antagonist targeting cardiovascular, renal, and metabolic indications) defines a differentiated therapeutics opportunity within a multi-billion-dollar global hypertension and heart-failure market where current therapies have meaningful tolerance limitations. The defining Q1 signals: Wellington Management added $63M alongside Caligan Partners reducing $109M — a rotation consistent with fundamental biotech conviction allocation into late-clinical-stage cardiovascular assets being built or trimmed at the manager tier as clinical-readout timelines approach. For smart-money trackers, MLYS's institutional footprint reflects the selective-mineralocorticoid-receptor thesis and the late-pre-commercial cardiovascular biotech allocation pattern, where Q/Q rotation is most useful when evaluated against the company's ongoing Phase program activity, regulatory engagement milestones, and potential big-pharma partnering or acquisition interest that typically peaks ahead of pivotal Phase 3 readouts.

Addressable market: hypertension (resistant hypertension in particular), heart failure (HFrEF and HFpEF), chronic kidney disease (CKD). Market size: hundreds of millions of patients globally on some form of antihypertensive therapy. Adding a differentiated MRA with fewer side effects represents potential multi-billion-dollar revenue opportunity if pivotal trials succeed.

Q1 2026 context: clinical-stage cardiovascular biotech — valuation and institutional holder base are driven by (1) Phase 2 readout quality, (2) Phase 3 trial design and timelines, (3) end of Phase 2 / pre-Phase 3 FDA engagement meeting, (4) big-pharma partnership interest. Major binary catalysts: Phase 2A readouts, Phase 3 initiation. The $2.5B / 205 holder count reflects conviction among cardiovascular-focused biotech managers.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
Catalys Pacific, LLC
CIK 0002011385
$214M7.9M92.81%Q1 2026
02
RA CAPITAL MANAGEMENT, L.P.
CIK 0001346824
$208M7.7M2.21%Q1 2026
03
Samsara BioCapital, LLC
CIK 0001744967
$159M5.9M15.45%Q1 2026
04
FMR LLC
CIK 0000315066
$132M4.9M0.01%Q1 2026
05
BlackRock, Inc.
CIK 0002012383
$121M4.5M0.00%Q1 2026
06
WELLINGTON MANAGEMENT GROUP LLP
CIK 0000902219
$91M3.4M0.02%Q1 2026
07
Caption Management, LLC
CIK 0001706766
$89M3.3M0.52%Q1 2026
08
STATE STREET CORP
CIK 0000093751
$80M2.9M0.00%Q1 2026
09
Caligan Partners LP
CIK 0001727492
$75M2.8M5.00%Q1 2026
10
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$66M2.5M0.00%Q1 2026
11
Laurion Capital Management LP
CIK 0001390202
$60M2.2M2.64%Q1 2026
12
ORBIMED ADVISORS LLC
CIK 0001055951
$56M2.1M1.11%Q1 2026
13
Point72 Asset Management, L.P.
CIK 0001603466
$52M1.9M0.07%Q1 2026
14
FRANKLIN RESOURCES INC
CIK 0000038777
$48M1.8M0.01%Q1 2026
15
BOOTHBAY FUND MANAGEMENT, LLC
CIK 0001549230
$47M1.7M0.60%Q1 2026
16
JENNISON ASSOCIATES LLC
CIK 0000053417
$46M1.3M0.03%Q4 2025
17
Andera Partners
CIK 0001757283
$43M1.6M20.80%Q2 2026
18
SR ONE CAPITAL MANAGEMENT, LP
CIK 0001910264
$42M1.6M4.63%Q1 2026
19
D. E. Shaw & Co., Inc.
CIK 0001009207
$42M1.2M0.02%Q4 2025
20
SUVRETTA CAPITAL MANAGEMENT, LLC
CIK 0001569064
$42M1.5M1.06%Q1 2026
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Insiders at MINERALYS THERAPEUTICS INC
Warren EricRodman David MalcomCongleton JonKarydas Daphne