13F Insight
DOSSIER · 13F Holders · Q1 2026BellwetherCompounder
OBIO

ORCHESTRA BIOMED HLDGS INC

69 institutions still hold ORCHESTRA BIOMED HLDGS INC as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 68572M106·69 13F holders·last filed Mar 31, 2026
Market cap
—
▼ 8.0%
vs prior quarter
13F value held
$92M
45.0% inst. owned
of float
Holders
69
+71 QoQ
filers reporting
Activity
+69 / −79
+843 added · −776 reduced
this quarter
Concentration
38.33%
RTW INVESTMENTS, LP #1
top holder share
AI Holders Summary · Q1 2026

69 institutions reported OBIO in Q1 2026. RTW INVESTMENTS, LP leads at 38.3% of the visible book. +71 net new institutions vs prior quarter — accumulation reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
RTW INVESTMENTS, LP
CIK 0001493215
$35M8.3M0.35%Q1 202602
PERCEPTIVE ADVISORS LLC
CIK 0001224962
$21M5.0M0.42%Q1 202603
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$9M2.2M0.00%Q1 202604
Alyeska Investment Group, L.P.
CIK 0001453072
$4M1.0M0.01%Q4 202505
Propel Bio Management, LLC
CIK 0001969764
$4M897K2.41%Q1 202606
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
$3M703K0.00%Q1 202607
BlackRock, Inc.
CIK 0002012383
$3M636K0.00%Q1 202608
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$2M485K0.00%Q1 202609
Affinity Asset Advisors, LLC
CIK 0001773195
$2M403K0.09%Q1 202610
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
CIK 0000884546· Index
$1M265K0.00%Q1 202611
Knott David M Jr
CIK 0001892770
$1M254K0.64%Q1 202612
VANGUARD FIDUCIARY TRUST CO
CIK 0000933478· Index
$999,660235K0.00%Q1 202613
Simplify Asset Management Inc.
CIK 0001846368
$932,395219K0.01%Q1 202614
683 Capital Management, LLC
CIK 0001404574
$846,915204K0.04%Q4 202515
STATE STREET CORP
CIK 0000093751
$719,993169K0.00%Q1 202616
MARSHALL WACE, LLP
CIK 0001318757
$712,476172K0.00%Q4 202517
GOLDMAN SACHS GROUP INC
CIK 0000886982
$659,779155K0.00%Q1 202618
DAFNA Capital Management LLC
CIK 0001389933
$539,074127K0.12%Q1 202619
NORTHERN TRUST CORP
CIK 0000073124· Index
$502,665118K0.00%Q1 202620
Qube Research & Technologies Ltd
CIK 0001729829
$463,050109K0.00%Q1 2026
Page 1 of 4
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