DOSSIER · 13F-HR · Q2 2026

Propel Bio Management, LLC

$191M in tracked AUM across 29 positions as of Q2 2026.

PB
CIK 0001969764 · last filed Jun 30, 2026
Total AUM
$191M
as of Q2 2026
Holdings
29
positions
Whale Score
64
64
tracked
Activity
no data
changes this Q
AI Analysis · Q2 2026

SEC 13F Filing Analysis: Propel Bio Management, LLC

Report Period: Q3 2025 (Ending September 30, 2025)

1. Portfolio Overview

Propel Bio Management, LLC manages a concentrated portfolio totaling approximately $80.53 million across 12 holdings. The firm’s strategy is characterized by high conviction and low diversification, with the top four positions comprising nearly 64% of the total assets under management (AUM). During the third quarter of 2025, the firm executed a sig...

2. Key Holdings

The portfolio is dominated by Plains GP Holdings (PAGP), which accounts for 28.82% ($23.21M) of the fund. This represents a massive outlier position relative to the rest of the holdings, which are exclusively healthcare/biotech firms. PAGP provides the portfolio with a value and income tilt, likely serving as a liquidity buffer or a hedge against the volatility inherent in the firm's speculative healthcare positions.

The remaining top holdings are exclusively clinical-stage biotechnology companies:

  • Akero Therapeutics (AKRO) is the second-largest holding at 13.50% ($10.87M).
  • Milestone Pharmaceuticals represents 12.73% ($10.25M) and was the subject of aggressive accumulation during the quarter.
  • Applied Therapeutics and Phathom Pharmaceuticals round out the top five, with allocations of 8.48% and 8.08%, respectively.
Analysis generated by 13F Insight from SEC Form 13F filing data · Q2 2026. Methodology

Quarter at a glance — Q2 2026

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q2 2026.

#HoldingValueSharesWeight
01
PAGP
PLAINS GP HOLDINGS LP-CL
$31M1.3M16.2%
02
ACHV
ACHIEVE LIFE SCIENCES INC
$26M4.0M13.8%
03
CORT
CORCEPT THERAPEUTICS INC
$12M136K6.2%
04
PHAT
PHATHOM PHARMACEUTICALS I
$11M1.1M6.0%
05
DCTH
DELCATH SYSTEMS INC
$11M871K5.7%
06
MIST
MILESTONE PHARMACEUTICALS
$10M7.4M5.2%
07
CMPS
COMPASS PATHWAYS PLC
$8M573K4.2%
08
KYTX
KYVERNA THERAPEUTICS INC
$8M883K4.1%
09
ARTV
ARTIVA BIOTHERAPEUTICS IN
$7M696K3.5%
10
ABEO
ABEONA THERAPEUTICS INC
$6M983K3.2%

Filing history

2026Q2Jun 30
$191M 20.4%
29 positionsView →
2026Q1Mar 31
$159M 35.5%
38 positionsView →
2025Q4Dec 31
$117M 45.4%
20 positionsView →
2025Q3Sep 30
$81M 2.3%
12 positionsView →
2025Q2Jun 30
$82M 20.8%
16 positionsLocked
2025Q1Mar 31
$68M 32.2%
15 positionsLocked
2024Q4Dec 31
$101M 41.6%
21 positionsLocked
2024Q3Sep 30
$172M 11.8%
21 positionsLocked
2024Q2Jun 30
$154M 10.3%
25 positionsLocked
2024Q1Mar 31
$172M 42.4%
29 positionsLocked
2023Q4Dec 31
$121M
34 positionsLocked