AI Holders Summary · Q4 2025

210 institutions reported REPL in Q4 2025. BAKER BROS. ADVISORS LP leads at 12.9% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(3 on this page)

#HolderValueShares% port.Quarter

BAKER BROS. ADVISORS LP

CIK 0001263508

$107M11.0M0.63%Q4 2025 02

BlackRock, Inc.

CIK 0002012383

$99M9.0M0.00%Q2 2026 03

RTW INVESTMENTS, LP

CIK 0001493215

$82M7.4M0.70%Q2 2026 04

PRICE T ROWE ASSOCIATES INC /MD/

CIK 0000080255

$62M8.1M0.01%Q1 2026 05

GOLDMAN SACHS GROUP INC

CIK 0000886982

$50M4.6M0.00%Q2 2026 06

STATE STREET CORP

CIK 0000093751

$49M4.4M0.00%Q2 2026 07

Boxer Capital Management, LLC

CIK 0002018299

$44M4.0M3.32%Q2 2026 08

Caption Management, LLC

CIK 0001706766

$44M4.0M0.20%Q2 2026 09

SUVRETTA CAPITAL MANAGEMENT, LLC

CIK 0001569064

$32M4.2M0.82%Q1 2026 10

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$32M2.9M0.00%Q2 2026 11

FCPM III SERVICES B.V.

CIK 0002013410

$31M2.8M4.14%Q2 2026 12

AQR CAPITAL MANAGEMENT LLC

CIK 0001167557

$28M2.6M0.01%Q2 2026 13

Logos Global Management LP

CIK 0001792126

$28M2.5M1.19%Q2 2026 14

D. E. Shaw & Co., Inc.

CIK 0001009207

$25M2.6M0.01%Q4 2025 15

Erste Asset Management GmbH

CIK 0002024532

$24M2.1M0.18%Q2 2026 16

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$23M2.0M0.00%Q2 2026 17

CITADEL ADVISORS LLC

CIK 0001423053

$21M1.9M0.00%Q2 2026 18

SUSQUEHANNA INTERNATIONAL GROUP, LLP

CIK 0001446194· Market maker

$20M1.8M0.00%Q2 2026 19

Opaleye Management Inc.

CIK 0001595855

$15M1.4M1.39%Q2 2026 20

TORONTO DOMINION BANK

CIK 0000947263

$14M1.3M0.02%Q2 2026

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