AI Holders Summary · Q4 2025

205 institutions reported REPL in Q4 2025. BAKER BROS. ADVISORS LP leads at 19.7% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(4 on this page)

#HolderValueShares% port.Quarter

BAKER BROS. ADVISORS LP

CIK 0001263508

$107M11.0M0.63%Q4 2025 02

PRICE T ROWE ASSOCIATES INC /MD/

CIK 0000080255

$62M8.1M0.01%Q1 2026 03

RTW INVESTMENTS, LP

CIK 0001493215

$56M7.4M0.56%Q1 2026 04

BlackRock, Inc.

CIK 0002012383

$48M6.2M0.00%Q1 2026 05

SUVRETTA CAPITAL MANAGEMENT, LLC

CIK 0001569064

$32M4.2M0.82%Q1 2026 06

STATE STREET CORP

CIK 0000093751

$29M3.8M0.00%Q1 2026 07

D. E. Shaw & Co., Inc.

CIK 0001009207

$25M2.6M0.01%Q4 2025 08

FCPM III SERVICES B.V.

CIK 0002013410

$21M2.8M2.97%Q1 2026 09

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$21M2.8M0.00%Q1 2026 10

SUSQUEHANNA INTERNATIONAL GROUP, LLP

CIK 0001446194· Market maker

$18M2.3M0.00%Q1 2026 11

GOLDMAN SACHS GROUP INC

CIK 0000886982

$17M2.3M0.00%Q1 2026 12

FMR LLC

CIK 0000315066

$16M2.0M0.00%Q1 2026 13

Erste Asset Management GmbH

CIK 0002024532

$15M2.1M0.14%Q1 2026 14

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$14M1.8M0.00%Q1 2026 15

ADAR1 Capital Management, LLC

CIK 0001940272

$13M1.7M0.76%Q1 2026 16

TORONTO DOMINION BANK

CIK 0000947263

$12M1.6M0.02%Q1 2026 17

Caption Management, LLC

CIK 0001706766

$11M1.4M0.06%Q1 2026 18

Boxer Capital Management, LLC

CIK 0002018299

$9M1.2M1.18%Q1 2026 19

DIMENSIONAL FUND ADVISORS LP

CIK 0000354204· Quasi-passive

$9M1.1M0.00%Q1 2026 20

Sofinnova Investments, Inc.

CIK 0001631134

$8M1.0M0.30%Q1 2026

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