DOSSIER · 13F Holders · Q1 2026
SPRO

SPERO THERAPEUTICS INC

53 institutions still hold SPERO THERAPEUTICS INC as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 84833T103·53 13F holders·last filed Mar 31, 2026
Market cap
13F value held
$49M
visible holders
Holders
53
filers reporting
Concentration
44.32%
GSK plc #1
top holder share
AI Holders Summary · Q1 2026

53 institutions reported SPRO in Q1 2026. GSK plc leads at 44.3% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
GSK plc
CIK 0001131399
$22M9.2M3.59%Q1 2026
02
PFIZER INC
CIK 0000078003
$6M2.4M2.31%Q1 2026
03
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$4M1.8M0.00%Q1 2026
04
RENAISSANCE TECHNOLOGIES LLC
CIK 0001037389
$3M1.2M0.00%Q1 2026
05
Alphabet Inc.
CIK 0001652044
$2M890K0.05%Q1 2026
06
TWO SIGMA INVESTMENTS, LP
CIK 0001179392
$2M886K0.00%Q1 2026
07
Anson Funds Management LP
CIK 0001491072
$2M844K0.09%Q1 2026
08
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$1M520K0.00%Q1 2026
09
CITADEL ADVISORS LLC
CIK 0001423053
$1M471K0.00%Q4 2025
10
BlackRock, Inc.
CIK 0002012383
$1M433K0.00%Q1 2026
11
SUSQUEHANNA INTERNATIONAL GROUP, LLP
CIK 0001446194· Market maker
$893K382K0.00%Q1 2026
12
GSA CAPITAL PARTNERS LLP
CIK 0001362033
$651K278K0.04%Q1 2026
13
VANGUARD FIDUCIARY TRUST CO
CIK 0000933478· Index
$618K264K0.00%Q1 2026
14
TWO SIGMA ADVISERS, LP
CIK 0001478735
$505K217K0.00%Q4 2025
15
STATE STREET CORP
CIK 0000093751
$503K215K0.00%Q1 2026
16
Ionic Capital Management LLC
CIK 0001386462
$457K196K0.06%Q4 2025
17
Squarepoint Ops LLC
CIK 0001642575
$455K194K0.00%Q1 2026
18
JANE STREET GROUP, LLC
CIK 0001595888· Market maker
$427K183K0.00%Q1 2026
19
NORTHERN TRUST CORP
CIK 0000073124· Index
$283K121K0.00%Q1 2026
20
BRIDGEWAY CAPITAL MANAGEMENT, LLC
CIK 0001107261
$269K115K0.01%Q1 2026
Page 1 of 3
33 more holders available. Log in →
Insiders at SPERO THERAPEUTICS INC
Deshpande MilindVink Patrick V.J.J.Tregoning KathleenSmith CynthiaPottage John C JrJackson Scott ThomasThomas Frank ERajavelu Esther