13F Insight
DOSSIER · 13F Holders · Q1 2026Inflation hedgeYield
UPB

UPSTREAM BIO INC

152 institutions still hold UPSTREAM BIO INC as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 91678A107·152 13F holders·last filed Mar 31, 2026
Market cap
—
▲ 8.5%
vs prior quarter
13F value held
$355M
61.0% inst. owned
of float
Holders
152
+32 QoQ
filers reporting
Activity
+68 / −7
+940 added · −810 reduced
this quarter
Concentration
20.54%
FMR LLC #1
top holder share
AI Holders Summary · Q1 2026

152 institutions reported UPB in Q1 2026. FMR LLC leads at 20.5% of the visible book. +32 net new institutions vs prior quarter — accumulation reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
FMR LLC
CIK 0000315066
$73M8.1M0.00%Q1 202602
ORBIMED ADVISORS LLC
CIK 0001055951
$51M5.7M1.02%Q1 202603
VR Adviser, LLC
CIK 0001615982
$32M1.2M1.57%Q4 202504
BlackRock, Inc.
CIK 0002012383
$30M3.4M0.00%Q1 202605
Decheng Capital LLC
CIK 0002010850
$25M2.7M3.71%Q1 202606
Enavate Sciences GP, LLC
CIK 0001953107
$22M2.5M6.30%Q1 202607
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$17M1.9M0.00%Q1 202608
MARSHALL WACE, LLP
CIK 0001318757
$9M344K0.01%Q4 202509
Y-Intercept (Hong Kong) Ltd
CIK 0001772875
$9M1.0M0.17%Q1 202610
FEDERATED HERMES, INC.
CIK 0001056288
$9M980K0.01%Q1 202611
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$9M951K0.00%Q1 202612
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
$8M937K0.00%Q1 202613
GREAT POINT PARTNERS LLC
CIK 0001281446
$8M300K2.64%Q4 202514
Alyeska Investment Group, L.P.
CIK 0001453072
$8M298K0.02%Q4 202515
SEB Asset Management AB
CIK 0002127509
$8M878K0.03%Q1 202616
JENNISON ASSOCIATES LLC
CIK 0000053417
$8M289K0.00%Q4 202517
Bain Capital Life Sciences Investors, LLC
CIK 0001703031
$8M867K0.70%Q1 202618
Woodline Partners LP
CIK 0001784547
$7M831K0.03%Q1 202619
Parkman Healthcare Partners LLC
CIK 0001777015
$7M787K0.73%Q1 202620
Samsara BioCapital, LLC
CIK 0001744967
$7M736K0.64%Q1 2026
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