DOSSIER · 13F Holders · Q2 2026
UPB

UPSTREAM BIO INC

151 institutions still hold UPSTREAM BIO INC as of Q2 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 91678A107·151 13F holders·last filed Jun 30, 2026
Market cap
13F value held
$305M
visible holders
Holders
151
filers reporting
Concentration
18.53%
FMR LLC #1
top holder share
AI Holders Summary · Q2 2026

151 institutions reported UPB in Q2 2026. FMR LLC leads at 18.5% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
FMR LLC
CIK 0000315066
$56M8.2M0.00%Q2 2026
02
ORBIMED ADVISORS LLC
CIK 0001055951
$39M5.7M0.73%Q2 2026
03
VR Adviser, LLC
CIK 0001615982
$32M1.2M1.57%Q4 2025
04
NORGES BANK
CIK 0001374170· Sovereign
$26M3.8M0.00%Q2 2026
05
BlackRock, Inc.
CIK 0002012383
$26M3.8M0.00%Q2 2026
06
Decheng Capital LLC
CIK 0002010850
$19M2.7M2.58%Q2 2026
07
Enavate Sciences GP, LLC
CIK 0001953107
$17M2.5M4.93%Q2 2026
08
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$13M1.9M0.00%Q2 2026
09
GREAT POINT PARTNERS LLC
CIK 0001281446
$8M300K2.64%Q4 2025
10
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
$8M1.1M0.00%Q2 2026
11
JPMORGAN CHASE & CO
CIK 0000019617
$7M1.0M0.00%Q2 2026
12
Qube Research & Technologies Ltd
CIK 0001729829
$7M979K0.01%Q2 2026
13
Samsara BioCapital, LLC
CIK 0001744967
$7M736K0.64%Q1 2026
14
Parkman Healthcare Partners LLC
CIK 0001777015
$6M935K0.66%Q2 2026
15
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$6M931K0.00%Q2 2026
16
SEB Asset Management AB
CIK 0002127509
$6M878K0.02%Q2 2026
17
Woodline Partners LP
CIK 0001784547
$6M831K0.02%Q2 2026
18
STATE STREET CORP
CIK 0000093751
$5M766K0.00%Q2 2026
19
Vanguard Portfolio Management
CIK 0002100121· Index
$5M713K0.00%Q2 2026
20
Y-Intercept (Hong Kong) Ltd
CIK 0001772875
$5M694K0.10%Q2 2026
Page 1 of 8
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Insiders at UPSTREAM BIO INC
Ratcliffe LiamChimovits ErezBeckman DaniellaRenaud Ronald C JrFleming Harold EdwardRuddy Marcella K.Ambrose AllisonDeykin Aaron