DOSSIER · 13F-HR · Q4 2025

Flagship Pioneering Inc.

$324M in tracked AUM across 6 positions as of Q4 2025.

FP
CIK 0001400240 · last filed Dec 31, 2025
Total AUM
$324M
as of Q4 2025
Holdings
6
positions
Whale Score
65
65
tracked
Activity
no data
changes this Q
AI Analysis · Q4 2025

Portfolio Overview

Flagship Pioneering Inc.’s SEC 13F filing for the period ending September 30, 2025, reveals a highly concentrated and specialized investment portfolio. The total portfolio value decreased substantially by 47.1%, contracting from approximately $268.47 million in the previous quarter to $141.89 million. This reduction is not solely attributable to market depreciation but is primarily driven by significant capital reallocation, evidenced by the liquidation of two major posit...

Key Holdings

The portfolio is dominated by two primary positions that together account for the entire reported value. The largest holding is Moderna Inc (MRNA), valued at $119.65 million, representing a massive 84.33% of the total portfolio. Flagship holds 4.63 million shares of MRNA, a position that underscores the firm's deep-rooted connection to the company, as Flagship was the foundational investor behind Moderna.

Quarter at a glance — Q4 2025

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q4 2025.

#HoldingValueSharesWeight
01
MRNA
Moderna Inc
$137M4.6M42.2%
02
SANA
Sana Biotechnology Inc
$102M25.0M31.4%
03
FHTX
Foghorn Therapeutics Inc
$68M12.7M21.1%
04
MCRB
Seres Therapeutics Inc
$17M1.2M5.3%

Filing history

2025Q4Dec 31
$324M 128.4%
6 positionsView →
2025Q3Sep 30
$142M 47.1%
4 positionsView →
2025Q2Jun 30
$268M 82.0%
8 positionsLocked
2025Q1Mar 31
$148M 55.9%
4 positionsLocked
2024Q4Dec 31
$334M 43.5%
10 positionsLocked
2024Q3Sep 30
$592M 29.8%
12 positionsLocked
2024Q2Jun 30
$843M 44.7%
12 positionsLocked
2024Q1Mar 31
$1.5B 15.0%
13 positionsLocked
2023Q4Dec 31
$1.3B 3.8%
13 positionsLocked
2023Q3Sep 30
$1.4B 38.5%
18 positionsLocked
2023Q2Jun 30
$2.2B 12.9%
20 positionsLocked
2023Q1Mar 31
$2.6B 17.8%
22 positionsLocked
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