AI Holders Summary · Q4 2025

168 institutions reported LRMR in Q4 2025. DEERFIELD MANAGEMENT COMPANY, L.P. leads at 44.1% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(4 on this page)

#HolderValueShares% port.Quarter

DEERFIELD MANAGEMENT COMPANY, L.P.

CIK 0001009258

$117M30.6M1.49%Q4 2025 02

Blue Owl Capital Holdings LP

CIK 0001858703

$28M9.2M4.21%Q2 2026 03

BlackRock, Inc.

CIK 0002012383

$17M5.7M0.00%Q2 2026 04

Defilade Capital Management, L.P.

CIK 0002088557

$11M3.7M1.50%Q2 2026 05

DRIEHAUS CAPITAL MANAGEMENT LLC

CIK 0000938206

$10M3.2M0.06%Q2 2026 06

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$9M3.0M0.00%Q2 2026 07

RTW INVESTMENTS, LP

CIK 0001493215

$8M2.6M0.07%Q2 2026 08

AQR CAPITAL MANAGEMENT LLC

CIK 0001167557

$7M2.4M0.00%Q2 2026 09

MARSHALL WACE, LLP

CIK 0001318757

$6M2.0M0.00%Q2 2026 10

DAFNA Capital Management LLC

CIK 0001389933

$6M2.0M1.17%Q2 2026 11

GOLDMAN SACHS GROUP INC

CIK 0000886982

$6M1.8M0.00%Q2 2026 12

CITADEL ADVISORS LLC

CIK 0001423053

$5M1.7M0.00%Q2 2026 13

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$5M1.7M0.00%Q2 2026 14

Qube Research & Technologies Ltd

CIK 0001729829

$5M1.6M0.00%Q2 2026 15

Point72 Asset Management, L.P.

CIK 0001603466

$5M1.0M0.01%Q1 2026 16

STATE STREET CORP

CIK 0000093751

$4M1.4M0.00%Q2 2026 17

Vanguard Portfolio Management

CIK 0002100121· Index

$4M1.4M0.00%Q2 2026 18

Woodline Partners LP

CIK 0001784547

$4M1.4M0.01%Q2 2026 19

MILLENNIUM MANAGEMENT LLC

CIK 0001273087

$4M1.3M0.00%Q2 2026 20

JANE STREET GROUP, LLC

CIK 0001595888· Market maker

$3M657K0.00%Q1 2026

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