AI Holders Summary · Q4 2025

45 institutions reported SKYE in Q4 2025. 5AM Venture Management, LLC leads at 63.4% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(4 on this page)

#HolderValueShares% port.Quarter

5AM Venture Management, LLC

CIK 0001799883

$7M9.7M2.28%Q4 2025 02

Versant Venture Management, LLC

CIK 0001560009

$1M2.0M0.87%Q1 2026 03

BAKER BROS. ADVISORS LP

CIK 0001263508

$1M1.5M0.01%Q4 2025 04

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$470K764K0.00%Q1 2026 05

SPHERA FUNDS MANAGEMENT LTD.

CIK 0001496201

$417K679K0.07%Q1 2026 06

BlackRock, Inc.

CIK 0002012383

$176K286K0.00%Q1 2026 07

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$170K277K0.00%Q1 2026 08

MILLENNIUM MANAGEMENT LLC

CIK 0001273087

$159K258K0.00%Q1 2026 09

PLATINUM INVESTMENT MANAGEMENT LTD

CIK 0001256071

$143K233K0.04%Q1 2026 10

VANGUARD FIDUCIARY TRUST CO

CIK 0000933478· Index

$64K104K0.00%Q1 2026 11

CITADEL ADVISORS LLC

CIK 0001423053

$62K83K0.00%Q4 2025 12

STATE STREET CORP

CIK 0000093751

$46K75K0.00%Q1 2026 13

TWO SIGMA ADVISERS, LP

CIK 0001478735

$31K41K0.00%Q4 2025 14

UBS Group AG

CIK 0001610520

$28K46K0.00%Q1 2026 15

XTX Topco Ltd

CIK 0001828301

$25K41K0.00%Q1 2026 16

HRT FINANCIAL LP

CIK 0001475597

$20K27K0.00%Q4 2025 17

TWO SIGMA INVESTMENTS, LP

CIK 0001179392

$16K26K0.00%Q1 2026 18

Engineers Gate Manager LP

CIK 0001620220

$12K20K0.00%Q1 2026 19

NORTHERN TRUST CORP

CIK 0000073124· Index

$12K20K0.00%Q1 2026 20

BARCLAYS PLC

CIK 0000312069

$11K18K0.00%Q1 2026

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