13F Insight
DOSSIER · 13F Holders · Q4 2025Cheap mega-capRe-rated
SKYE

SKYE BIOSCIENCE INC

44 institutions still hold SKYE BIOSCIENCE INC as of Q4 2025. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 83086J200·44 13F holders·last filed Dec 31, 2025
Market cap
—
▼ 3.9%
vs prior quarter
13F value held
$11M
45.0% inst. owned
of float
Holders
44
-51 QoQ
filers reporting
Activity
+88 / −106
+875 added · −679 reduced
this quarter
Concentration
63.43%
5AM Venture Management, LLC #1
top holder share
AI Holders Summary · Q4 2025

44 institutions reported SKYE in Q4 2025. 5AM Venture Management, LLC leads at 63.4% of the visible book. -51 net institutions QoQ — distribution reading.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
5AM Venture Management, LLC
CIK 0001799883
$7M9.7M2.28%Q4 202502
Versant Venture Management, LLC
CIK 0001560009
$1M2.0M0.87%Q1 202603
BAKER BROS. ADVISORS LP
CIK 0001263508
$1M1.5M0.01%Q4 202504
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$470,141764K0.00%Q1 202605
SPHERA FUNDS MANAGEMENT LTD.
CIK 0001496201
$417,269679K0.07%Q1 202606
BlackRock, Inc.
CIK 0002012383
$175,855286K0.00%Q1 202607
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$170,447277K0.00%Q1 202608
MILLENNIUM MANAGEMENT LLC
CIK 0001273087
$158,690258K0.00%Q1 202609
PLATINUM INVESTMENT MANAGEMENT LTD
CIK 0001256071
$143,260233K0.04%Q1 202610
VANGUARD FIDUCIARY TRUST CO
CIK 0000933478· Index
$64,101104K0.00%Q1 202611
CITADEL ADVISORS LLC
CIK 0001423053
$62,00183K0.00%Q4 202512
STATE STREET CORP
CIK 0000093751
$46,29575K0.00%Q1 202613
TWO SIGMA ADVISERS, LP
CIK 0001478735
$30,72441K0.00%Q4 202514
UBS Group AG
CIK 0001610520
$28,14346K0.00%Q1 202615
XTX Topco Ltd
CIK 0001828301
$25,14941K0.00%Q1 202616
HRT FINANCIAL LP
CIK 0001475597
$20,00027K0.00%Q4 202517
TWO SIGMA INVESTMENTS, LP
CIK 0001179392
$15,78526K0.00%Q1 202618
Engineers Gate Manager LP
CIK 0001620220
$12,41120K0.00%Q1 202619
NORTHERN TRUST CORP
CIK 0000073124· Index
$12,37920K0.00%Q1 202620
BARCLAYS PLC
CIK 0000312069
$11,11718K0.00%Q1 2026
Page 1 of 3
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