AI Holders Summary · Q4 2025

217 institutions reported SPRY in Q4 2025. DEERFIELD MANAGEMENT COMPANY, L.P. leads at 13.8% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(2 on this page)

#HolderValueShares% port.Quarter

DEERFIELD MANAGEMENT COMPANY, L.P.

CIK 0001009258

$87M7.5M1.12%Q4 2025 02

RA CAPITAL MANAGEMENT, L.P.

CIK 0001346824

$87M10.9M0.76%Q2 2026 03

Rubric Capital Management LP

CIK 0001687509

$68M8.5M0.63%Q2 2026 04

ORBIMED ADVISORS LLC

CIK 0001055951

$66M8.3M1.24%Q2 2026 05

BlackRock, Inc.

CIK 0002012383

$43M5.3M0.00%Q2 2026 06

Tyro Capital Management LLC

CIK 0001915395

$36M4.5M8.01%Q2 2026 07

Aberdeen Group plc

CIK 0001716774

$33M4.2M0.05%Q2 2026 08

SR ONE CAPITAL MANAGEMENT, LP

CIK 0001910264

$32M4.0M3.09%Q2 2026 09

STATE STREET CORP

CIK 0000093751

$30M3.7M0.00%Q2 2026 10

Capital World Investors

CIK 0001422849

$22M2.8M0.00%Q2 2026 11

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$20M2.6M0.00%Q2 2026 12

MILLENNIUM MANAGEMENT LLC

CIK 0001273087

$20M2.5M0.01%Q2 2026 13

Janney Montgomery Scott LLC

CIK 0001329948

$16M2.0M0.04%Q1 2026 14

UBS Group AG

CIK 0001610520

$16M1.9M0.00%Q2 2026 15

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$14M1.7M0.00%Q2 2026 16

BOOTHBAY FUND MANAGEMENT, LLC

CIK 0001549230

$13M1.6M0.17%Q2 2026 17

GENERAL AMERICAN INVESTORS CO INC

CIK 0000040417

$9M1.1M0.54%Q2 2026 18

Third Point LLC

CIK 0001040273

$8M1.0M0.17%Q2 2026 19

Nextech Invest, Ltd.

CIK 0001595430

$8M661K0.74%Q4 2025 20

PEREGRINE CAPITAL MANAGEMENT LLC

CIK 0000764529

$5M672K0.17%Q2 2026

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