ARCH Venture Management, LLC

Portfolio Overview

ARCH Venture Management’s 13F filing for the period ending September 30, 2025, reveals a highly concentrated, high-conviction portfolio with a distinct focus on early-stage and clinical-stage biotechnology. The firm manages approximately $384.90 million in assets across just 7 holdings, resulting in an average position size of roughly $55 million. This extreme lack of diversification—nearly 30% of the fund is allocated to a single security—indicates an investment ...