DOSSIER · 13F-HR · Q4 2025

GREAT POINT PARTNERS LLC

$308M in tracked AUM across 29 positions as of Q4 2025.

GP
CIK 0001281446 · last filed Dec 31, 2025
Total AUM
$308M
as of Q4 2025
Holdings
29
positions
Whale Score
63
63
tracked
Activity
no data
changes this Q
AI Analysis · Q4 2025

Comprehensive Analysis of GREAT POINT PARTNERS LLC SEC 13F Filing (Q3 2025)

1. Portfolio Overview

GREAT POINT PARTNERS LLC manages a concentrated, high-conviction portfolio totaling approximately $172.13 million across 19 holdings. The firm exhibits a distinct investment style characterized by high turnover and active management, evidenced by the portfolio's significant restructuring this quarter. The total portfolio value increased by 11.9% quarter-over-quarter (from $153.80M)...

The portfolio is highly concentrated, with the top 10 positions accounting for approximately 80% of total assets. The average position size is roughly 9.0%, indicating a willingness to take on idiosyncratic risk in exchange for potential upside. The presence of only one derivative position—a put option representing 0.37% of the portfolio—suggests the firm primarily relies on fundamental long-equity selection rather than complex hedging strategies.

2. Key Holdings

The portfolio is dominated by small-cap and mid-cap biotechnology and pharmaceutical companies, reflecting a specialized focus on clinical-stage healthcare.

Quarter at a glance — Q4 2025

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q4 2025.

#HoldingValueSharesWeight
01
APGE
APOGEE THERAPEUTICS INC
$28M374K9.2%
02
AMLX
AMYLYX PHARMACEUTICALS INC
$21M1.8M6.9%
03
G9TY5A101
ZURA BIO LTD
$20M3.8M6.5%
04
IRON
DISC MEDICINE INC
$20M250K6.4%
05
RAPT
RAPT THERAPEUTICS INC
$20M581K6.4%
06
IMVT
IMMUNOVANT INC
$19M750K6.2%
07
SLNO
SOLENO THERAPEUTICS INC
$19M400K6.0%
08
VOR
VOR BIOPHARMA INC
$18M1.4M5.8%
09
DNTH
DIANTHUS THERAPEUTICS INC
$14M350K4.7%
10
JBIO
JADE BIOSCIENCES INC
$12M806K4.0%

Filing history

2025Q4Dec 31
$308M 79.2%
29 positionsView →
2025Q3Sep 30
$172M 11.9%
19 positionsView →
2025Q2Jun 30
$154M 2.1%
26 positionsLocked
2025Q1Mar 31
$151M 29.0%
25 positionsLocked
2024Q4Dec 31
$212M 37.5%
26 positionsLocked
2024Q3Sep 30
$340M 34.9%
30 positionsLocked
2024Q2Jun 30
$522M 18.6%
33 positionsLocked
2024Q1Mar 31
$642M 9.4%
35 positionsLocked
2023Q4Dec 31
$587M 6.9%
34 positionsLocked
2023Q3Sep 30
$549M 7.5%
42 positionsLocked
2023Q2Jun 30
$511M 0.3%
40 positionsLocked
2023Q1Mar 31
$509M 0.2%
44 positionsLocked
Showing 12 of 55