DOSSIER · 13F-HR · Q4 2025

GREAT POINT PARTNERS LLC

GREAT POINT's hedge fund based in Stamford, CT — $308M in tracked AUM across 29 positions as of Q4 2025.

GP

GREAT POINT·Stamford, CT·Hedge Fund

CIK 0001281446 · last filed Dec 31, 2025

Total AUM

$308M

▲ 14.3%

vs prior

Holdings

29

—

positions

Whale Score

63

63

tracked

Activity

—

no data

changes this Q

Top sector

Tech

29% weight

concentration

AI Analysis · Q4 2025 · Q4 2025

Comprehensive Analysis of GREAT POINT PARTNERS LLC SEC 13F Filing (Q3 2025)

1. Portfolio Overview

GREAT POINT PARTNERS LLC manages a concentrated, high-conviction portfolio totaling approximately $172.13 million across 19 holdings. The firm exhibits a distinct investment style characterized by high turnover and active management, evidenced by the portfolio's significant restructuring this quarter. The total portfolio value increased by 11.9% quarter-over-quarter (from $153.80M)...

Quarter at a glance — Q4 2025

Position-change comparison pending.

No quarter-over-quarter changes available.

Top 10 holdings

By portfolio weight as of Q4 2025.

#HoldingValueSharesWeight

01

APOGEE THERAPEUTICS INC

$28M374K9.2%

02

AMYLYX PHARMACEUTICALS INC

$21M1.8M6.9%

03

ZURA BIO LTD

$20M3.8M6.5%

04

DISC MEDICINE INC

$20M250K6.4%

05

RAPT THERAPEUTICS INC

$20M581K6.4%

06

IMMUNOVANT INC

$19M750K6.2%

07

SOLENO THERAPEUTICS INC

$19M400K6.0%

08

VOR BIOPHARMA INC

$18M1.4M5.8%

09

DIANTHUS THERAPEUTICS INC

$14M350K4.7%

10

JADE BIOSCIENCES INC

$12M806K4.0%

Filing history

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