DOSSIER · 13F Holders · Q1 2026Healthcare · Pharmaceutical Preparations
ARWR

ARROWHEAD PHARMACEUTICALS IN

467 institutions still hold ARROWHEAD PHARMACEUTICALS IN as of Q1 2026. Tracked across SEC 13F-HR filings, with insider and 13D/G activity surfaced alongside.

CUSIP 04280A100·Pharmaceutical Preparations·467 13F holders·last filed Mar 31, 2026
Market cap
13F value held
$5.4B
visible holders
Holders
467
filers reporting
Concentration
21.23%
BlackRock, Inc. #1
top holder share
AI Holders Summary · Q1 2026

The two holders who 'control 91%' of Arrowhead Pharmaceuticals' tracked institutional value are, on inspection, two flavors of machinery: Assenagon Asset Management ($16.5 million after a $12.8 million add) is a quasi-passive options-overlay manager, and Y-Intercept ($3.3 million, new this quarter) is a quantitative shop with model-driven turnover. Neither position expresses a view on the RNAi biotech's pipeline. The genuinely discretionary layer of this 22-holder, $21.9 million base is strikingly thin — under $1.5 million in total, moving in five-figure increments: GAMMA Investing added $106,000, LRI Investments $168,000, and two advisors opened starter positions near $200,000 each, against Tema ETFs' $133,000 trim. For a clinical-stage biotech with real binary risk, the honest institutional-ownership read is an absence: fundamental institutions, in this tracked base, are barely present.

Assenagon Asset Management holds $16.5 million, three-quarters of the entire tracked base, after adding $12.8 million this quarter. It is classified quasi-passive: an options-overlay manager whose blocks appear at this scale across dozens of unrelated names each cycle as hedging books rebalance. Y-Intercept (Hong Kong), the new second-place holder at $3.3 million, is a quantitative manager whose systematic entries and exits routinely span quarters, not theses. Together they are 91% of the page and 0% of its fundamental signal.

What remains is the actual institutional footprint in the RNAi therapeutics developer, and it is small enough to describe completely: Financial Enhancement Group holds $448,000 (unchanged in shares, its value drift being price); GAMMA Investing added $106,000 to reach $316,000; LRI Investments added $168,000; CoreCap Advisors and PSP Research opened positions of $245,000 and $212,000; Tema ETFs trimmed $133,000. Total genuinely discretionary movement for the quarter: well under $1 million, in a company whose clinical pipeline carries billion-dollar-scale binary outcomes.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

#HolderValueShares% port.Quarter
01
BlackRock, Inc.
CIK 0002012383
$1.1B18.2M0.02%Q1 2026
02
Avoro Capital Advisors LLC
CIK 0001633313
$671M10.7M6.60%Q1 2026
03
FMR LLC
CIK 0000315066
$456M7.3M0.02%Q1 2026
04
Vanguard Portfolio Management
CIK 0002100121· Index
$448M7.1M0.02%Q1 2026
05
STATE STREET CORP
CIK 0000093751
$407M6.5M0.01%Q1 2026
06
VANGUARD CAPITAL MANAGEMENT LLC
CIK 0002100119· Index
$378M6.0M0.01%Q1 2026
07
GEODE CAPITAL MANAGEMENT, LLC
CIK 0001214717· Index
$275M4.3M0.02%Q1 2026
08
FRED ALGER MANAGEMENT, LLC
CIK 0000003520
$210M3.3M0.92%Q1 2026
09
Invesco Ltd.
CIK 0000914208
$206M3.3M0.02%Q1 2026
10
BAKER BROS. ADVISORS LP
CIK 0001263508
$144M2.2M0.85%Q4 2025
11
Vestal Point Capital, LP
CIK 0001974915
$143M2.3M3.99%Q1 2026
12
DEERFIELD MANAGEMENT COMPANY, L.P.
CIK 0001009258
$122M1.8M1.55%Q4 2025
13
SUSQUEHANNA INTERNATIONAL GROUP, LLP
CIK 0001446194· Market maker
$115M1.8M0.01%Q1 2026
14
GOLDMAN SACHS GROUP INC
CIK 0000886982
$109M1.7M0.01%Q1 2026
15
NORTHERN TRUST CORP
CIK 0000073124· Index
$104M1.7M0.01%Q1 2026
16
Siren, L.L.C.
CIK 0002005245
$101M1.6M2.81%Q1 2026
17
JANUS HENDERSON GROUP PLC
CIK 0001274173
$90M1.4M0.04%Q1 2026
18
UBS Group AG
CIK 0001610520
$84M1.3M0.01%Q1 2026
19
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC
CIK 0000861177
$83M1.3M0.02%Q1 2026
20
Pictet Asset Management Holding SA
CIK 0001993888
$80M1.3M0.08%Q1 2026
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Insiders at ARROWHEAD PHARMACEUTICALS IN
Cohen Matthew GregoryLu HongboHamilton James CApel Daniel JosephO'Brien PatrickAnzalone Christopher RichardFerrari MauroVakiener Victoria