AI Holders Summary · Q1 2026

201 institutions reported TSHA in Q1 2026. RA CAPITAL MANAGEMENT, L.P. leads at 10.5% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(2 on this page)

#HolderValueShares% port.Quarter

RA CAPITAL MANAGEMENT, L.P.

CIK 0001346824

$105M23.6M1.12%Q1 2026 02

GOLDMAN SACHS GROUP INC

CIK 0000886982

$100M22.4M0.01%Q1 2026 03

Avoro Capital Advisors LLC

CIK 0001633313

$97M21.7M0.95%Q1 2026 04

BlackRock, Inc.

CIK 0002012383

$82M18.4M0.00%Q1 2026 05

Vestal Point Capital, LP

CIK 0001974915

$80M18.0M2.25%Q1 2026 06

MORGAN STANLEY

CIK 0000895421

$80M18.0M0.00%Q1 2026 07

FMR LLC

CIK 0000315066

$64M14.3M0.00%Q1 2026 08

RTW INVESTMENTS, LP

CIK 0001493215

$61M13.7M0.61%Q1 2026 09

STATE STREET CORP

CIK 0000093751

$50M11.2M0.00%Q1 2026 10

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$46M10.2M0.00%Q1 2026 11

Octagon Capital Advisors LP

CIK 0001839435

$40M8.9M4.38%Q1 2026 12

Siren, L.L.C.

CIK 0002005245

$39M8.8M1.09%Q1 2026 13

Polar Capital Holdings Plc

CIK 0001837309

$25M5.7M0.09%Q1 2026 14

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$25M5.5M0.00%Q1 2026 15

GordonMD Global Investments LP

CIK 0002039349

$22M738K15.47%Q1 2026 16

D. E. Shaw & Co., Inc.

CIK 0001009207

$22M4.0M0.01%Q4 2025 17

BAKER BROS. ADVISORS LP

CIK 0001263508

$22M4.0M0.13%Q4 2025 18

DEERFIELD MANAGEMENT COMPANY, L.P.

CIK 0001009258

$15M2.7M0.19%Q4 2025 19

MILLENNIUM MANAGEMENT LLC

CIK 0001273087

$15M3.3M0.01%Q1 2026 20

Casdin Capital, LLC

CIK 0001534261

$15M3.3M1.10%Q1 2026

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