AI Holders Summary · Q2 2026

220 institutions reported TSHA in Q2 2026. Avoro Capital Advisors LLC leads at 10.7% of the visible book.

Top holders

Sorted by position value. Source: SEC EDGAR 13F-HR filings.

Hide index funds / market makers / custodians(2 on this page)

#HolderValueShares% port.Quarter

Avoro Capital Advisors LLC

CIK 0001633313

$163M23.9M1.46%Q2 2026 02

RA CAPITAL MANAGEMENT, L.P.

CIK 0001346824

$160M23.6M1.39%Q2 2026 03

GOLDMAN SACHS GROUP INC

CIK 0000886982

$155M22.7M0.01%Q2 2026 04

BlackRock, Inc.

CIK 0002012383

$141M20.7M0.00%Q2 2026 05

MORGAN STANLEY

CIK 0000895421

$112M16.5M0.01%Q2 2026 06

RTW INVESTMENTS, LP

CIK 0001493215

$92M13.6M0.79%Q2 2026 07

FMR LLC

CIK 0000315066

$91M13.3M0.00%Q2 2026 08

VANGUARD CAPITAL MANAGEMENT LLC

CIK 0002100119· Index

$85M12.5M0.00%Q2 2026 09

Vestal Point Capital, LP

CIK 0001974915

$80M18.0M2.25%Q1 2026 10

STATE STREET CORP

CIK 0000093751

$78M11.4M0.00%Q2 2026 11

Siren, L.L.C.

CIK 0002005245

$67M9.8M1.36%Q2 2026 12

Octagon Capital Advisors LP

CIK 0001839435

$66M9.7M5.93%Q2 2026 13

GEODE CAPITAL MANAGEMENT, LLC

CIK 0001214717· Index

$45M6.6M0.00%Q2 2026 14

Polar Capital Holdings Plc

CIK 0001837309

$35M5.1M0.08%Q2 2026 15

MPM BioImpact LLC

CIK 0001687078

$31M4.5M1.87%Q2 2026 16

WELLINGTON MANAGEMENT GROUP LLP

CIK 0000902219

$27M4.0M0.00%Q2 2026 17

HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND

CIK 0001535845

$26M3.9M0.04%Q2 2026 18

GordonMD Global Investments LP

CIK 0002039349

$25M723K11.86%Q2 2026 19

Casdin Capital, LLC

CIK 0001534261

$22M3.3M1.11%Q2 2026 20

D. E. Shaw & Co., Inc.

CIK 0001009207

$22M4.0M0.01%Q4 2025

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